469009

Sigma-Aldrich

2-Nitrophenyl phenyl sulfone

97%

Linear Formula:
O2NC6H4SO2C6H5
CAS Number:
Molecular Weight:
263.27
EC Number:
MDL number:
PubChem Substance ID:

assay

97%

mp

145-148 °C (lit.)

SMILES string

[O-][N+](=O)c1ccccc1S(=O)(=O)c2ccccc2

InChI

1S/C12H9NO4S/c14-13(15)11-8-4-5-9-12(11)18(16,17)10-6-2-1-3-7-10/h1-9H

InChI key

GKNMUCPEXSCGKC-UHFFFAOYSA-N

General description

2-Nitrophenyl phenyl sulfone (NPPS) is a substituted diarylsulfone derivative. It has been reported to protect the human CEM-SS lymphoblastoid cells from the cytopathic effects of HIV-1 in cell culture. Structure-activity relationship of 2-nitrophenyl phenyl sulfone has been studied.

Packaging

1 g in glass bottle

RIDADR

NONH for all modes of transport

WGK Germany

3

Certificate of Analysis
Certificate of Origin
J B McMahon et al.
Antimicrobial agents and chemotherapy, 37(4), 754-760 (1993-04-01)
A series of variously substituted diarylsulfones and related derivatives were found to prevent human immunodeficiency virus type 1 (HIV-1) replication and HIV-1-induced cell killing in vitro. One of the more potent derivatives, 2-nitrophenyl phenyl sulfone (NPPS), completely protected human CEM-SS...
M Artico et al.
Archiv der Pharmazie, 328(3), 223-229 (1995-03-01)
Various aryl 1-pyrryl sulfones were synthesized and tested as inhibitors of HIV-1. 2-Nitrophenyl-2-ethoxycarbonyl-1-pyrryl sulfone, the most active among test derivatives, was selected as lead compound of the aryl pyrryl sulfone series. The in vitro anti-HIV-1 activity and cytotoxicity of 41...

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