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473049

(1S,4S)-(−)-2-Boc-2,5-diazabicyclo[2.2.1]heptane

95%

Synonym(s):

tert-Butyl (1S,4S)-(−)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

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Pack SizeSKUAvailabilityPrice
1 g

Estimated to ship TODAYfromMILWAUKEE

$198.00
5 g

Estimated to ship TODAYfromMILWAUKEE

$559.00

About This Item

Empirical Formula (Hill Notation):
C10H18N2O2
CAS Number:
113451-59-5
Molecular Weight:
198.26
NACRES:
NA.22
PubChem Substance ID:
24870862
UNSPSC Code:
12352005
MDL number:
MFCD01569250
Assay:
95%

$198.00

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Quality Level

100

assay

95%

optical activity

[α]22/D −44°, c = 1 in chloroform

mp

74-76 °C (lit.)

SMILES string

CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2

InChI

1S/C10H18N2O2/c1-10(2,3)14-9(13)12-6-7-4-8(12)5-11-7/h7-8,11H,4-6H2,1-3H3/t7-,8-/m0/s1

InChI key

UXAWXZDXVOYLII-YUMQZZPRSA-N

Application

(1S,4S)-(-)-2-Boc-2,5-diazabicyclo[2.2.1]heptane may be used in the preparation of 2-boc-5-(4-nitrophenyl)-2,5-diaza-bicyclo[2.2.1]heptane by reacting with p-nitrobenzene.
It may also be used to develop:
  • indazolylpyrazolo[1,5-a]pyrimidine analogs based B-Raf inhibitors
  • CCR2 antagonists
  • α4β2 nicotinic acetylcholine receptor (nAChR) partial agonists
  • azabicyclic sulfonamide based 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCM7727
MKBZ1690V
MKBZ1688V
MKBQ4674V
MKBH0925

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Protocols

GC Analysis of Grob Test Mix SLB IL76i

GC Analysis of Grob Test Mix on SLB®-IL76i

Azabicyclic sulfonamides as potent 11?-HSD1 inhibitors.
Shah U, et al.
Bioorganic & Medicinal Chemistry Letters, 20(5), 1551-1554 (2010)
Indazolylpyrazolopyrimidine as highly potent B-Raf inhibitors with in vivo activity.
Wang Xi, et al.
Journal of Medicinal Chemistry, 53(21), 7874-7878 (2010)
Synthesis and biological evaluation of novel hybrids of highly potent and selective a4?2-Nicotinic acetylcholine receptor (nAChR) partial agonists.
Zhang HK, et al.
European Journal of Medicinal Chemistry, 124, 689-697 (2016)
View All Related Papers

Global Trade Item Number

SKUGTIN
473049-1G04061826129555
473049-5G04061832986173

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