474606

(S,S)-(+)-N,N′-Bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminocobalt(II)

• Synonym(s): (S,S)-Co(salen), (S,S)-Jacobsen HKR catalyst
• Linear Formula: [[[(CH₃)₃C]₂C₆H₂-2-(O-)CH=N]₂C₆H₁₀]Co
• CAS Number: 188264-84-8
• Molecular Weight: 603.74
• NACRES: NA.22
• PubChem Substance ID: 24871025
• UNSPSC Code: 12352001
• MDL number: MFCD01631278

Properties

• mp: >350 °C (lit.)
• Quality Segment: 200
• SMILES string: CC(C)(C)c1cc2C=[N@@H]3[C@H]4CCCC[C@@H]4[N@H]5=Cc6cc(cc(c6O[Co]35Oc2c(c1)C(C)(C)C)C(C)(C)C)C(C)(C)C
• InChI: 1S/C36H54N2O2.Co/c1-33(2,3)25-17-23(31(39)27(19-25)35(7,8)9)21-37-29-15-13-14-16-30(29)38-22-24-18-26(34(4,5)6)20-28(32(24)40)36(10,11)12;/h17-22,29-30,39-40H,13-16H2,1-12H3;/q;+2/p-2/b37-21+,38-22+;/t29-,30-;/m0./s1
• InChI key: ZFWPDJKMASHRPT-IKKUFEJKSA-L

Description

Application

(S,S)-(+)-N,N′-Bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminocobalt(II) may be used as a catalyst for the Jacobsen′s hydrolytic kinetic resolution of racemic epoxides, which is a key step during the multi-step synthesis of (+)-patulolide C, macrosphelides(I and G), (-)-(3S,6R)-3,6-dihydroxy-10-methylundecanoic acid, dodoneine, epidodoneine and protein kinase C epsilon (PKCe) inhibitors.

Catalyst for the hydrolytic kinetic resolution of terminal epoxides[1] and the enantioselective ring opening of meso epoxides.

Legal Information

Sold under license from Sterling Pharma Solutions Limited.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves