If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
47619
Fmoc-Ser(tBu)-OH
≥98.0% (HPLC), for peptide synthesis
Synonym(s):
Fmoc-O-tert-butyl-L-serine
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
10 g | Estimated to ship onJuly 06, 2026fromMILWAUKEE | $76.10 |
25 g | Estimated to ship onJuly 06, 2026fromMILWAUKEE | $102.00 |
100 g | Estimated to ship onJuly 06, 2026fromMILWAUKEE | $354.00 |
About This Item
Product Name
Fmoc-Ser(tBu)-OH, ≥98.0% (HPLC)
Quality Segment
assay
≥98.0% (HPLC)
form
powder
optical activity
[α]20/D +25.5±1°, c = 1% in ethyl acetate
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
application(s)
peptide synthesis
functional group
Fmoc
storage temp.
2-8°C
SMILES string
CC(C)(C)OC[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O
InChI
1S/C22H25NO5/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)/t19-/m0/s1
InChI key
REITVGIIZHFVGU-IBGZPJMESA-N
Application
- Total synthesis of an antibiotic, daptomycin, by cyclization via a chemoselective serine ligation.
- Preparation of MUC1, a T-cell helper peptide, using iterative pentafluorophenyl ester-mediated fragment condensations.
- Linear solid-phase peptide synthesis of ubiquitin and diubiquitin.
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This Item | |||
|---|---|---|---|
| form powder | form - | form - | form powder |
| functional group Fmoc | functional group Fmoc | functional group Fmoc | functional group Fmoc |
| assay ≥98.0% (HPLC) | assay ≥98.0% (TLC) | assay ≥97.0% (sum of enantiomers, HPLC) | assay ≥98.0% (HPLC) |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| optical activity [α]20/D +25.5±1°, c = 1% in ethyl acetate | optical activity - | optical activity [α]20/D −12.5±1°, c = 1% in DMF | optical activity [α]20/D −29±2°, c = 1% in DMF |
| reaction suitability reaction type: Fmoc solid-phase peptide synthesis | reaction suitability reaction type: Fmoc solid-phase peptide synthesis | reaction suitability reaction type: Fmoc solid-phase peptide synthesis | reaction suitability reaction type: Fmoc solid-phase peptide synthesis |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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How can I determine the shelf life / expiration / retest date of this product?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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What is the chiral purity of Fmoc-Ser(tBu)-OH?
1 answer-
Unfortunately, for this product the chiral purity (enantiomeric purity) is not determined. The certificate of analysis for each lot reports the specific rotation; this confirms that the vast majority of the material has the correct (+) chirality. But the ee (enantiomeric excess) is not calculated.
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