All Photos(1)

47834

Sigma-Aldrich

Fmoc-D-Phe(4-CF3)-OH

≥98.0%

Synonym(s):
Fmoc-4-(trifluoromethyl)-D-phenylalanine
Empirical Formula (Hill Notation):
C25H20F3NO4
CAS Number:
Molecular Weight:
455.43
MDL number:
PubChem Substance ID:
NACRES:
NA.26

Quality Level

assay

≥98.0%

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

application(s)

peptide synthesis: suitable

functional group

Fmoc

storage temp.

2-8°C

SMILES string

OC(=O)[C@@H](Cc1ccc(cc1)C(F)(F)F)NC(=O)OCC2c3ccccc3-c4ccccc24

InChI

1S/C25H20F3NO4/c26-25(27,28)16-11-9-15(10-12-16)13-22(23(30)31)29-24(32)33-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-12,21-22H,13-14H2,(H,29,32)(H,30,31)/t22-/m1/s1

InChI key

YMEGJWTUWMVZPD-JOCHJYFZSA-N

Certificate of Analysis

Certificate of Origin

Fayçal Touti et al.
Nature chemical biology, 15(4), 410-418 (2019-03-20)
The use of competitive inhibitors to disrupt protein-protein interactions (PPIs) holds great promise for the treatment of disease. However, the discovery of high-affinity inhibitors can be a challenge. Here we report a platform for improving the affinity of peptide-based PPI...

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