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486825

Sigma-Aldrich

L-Leucine-5,5,5-d3

99 atom % D

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Synonym(s):
SILAC Amino Acid
Linear Formula:
CH3CH(CD3)CH2CH(NH2)CO2H
CAS Number:
87828-86-2
Molecular Weight:
134.19
MDL number:
MFCD00144628
PubChem Substance ID:
24872215
NACRES:
NA.12

isotopic purity

99 atom % D

Quality Level

200

Assay

99% (CP)

form

solid

optical activity

[α]25/D +14.5°, c = 2 in 5 M HCl

technique(s)

protein expression: suitable

mp

>300 °C (lit.)

mass shift

M+3

SMILES string

[2H]C([2H])([2H])C(C)C[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1/i1D3/t4?,5-

InChI key

ROHFNLRQFUQHCH-LONBSJBQSA-N

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1 of 4

This Item
608092608068605239
L-Leucine-5,5,5-d3 99 atom % D

Sigma-Aldrich

486825

L-Leucine-5,5,5-d3

L-Isoleucine-13C6,15N 98 atom % 15N, 98 atom % 13C, 95% (CP)

Sigma-Aldrich

608092

L-Isoleucine-13C6,15N

L-Leucine-13C6,15N 98 atom % 13C, 98 atom % 15N, 95% (CP)

Sigma-Aldrich

608068

L-Leucine-13C6,15N

L-Leucine-13C6 98 atom % 13C, 95% (CP)

Sigma-Aldrich

605239

L-Leucine-13C6

assay

99% (CP)

assay

95% (CP)

assay

95% (CP)

assay

95% (CP)

form

solid

form

solid

form

solid

form

solid

technique(s)

protein expression: suitable

technique(s)

bio NMR: suitable, protein expression: suitable

technique(s)

bio NMR: suitable, protein expression: suitable

technique(s)

protein expression: suitable

mp

>300 °C (lit.)

mp

168-170 °C (lit.)

mp

>300 °C (lit.)

mp

>300 °C (lit.)

mass shift

M+3

mass shift

M+7

mass shift

M+7

mass shift

M+6

General description

L-leucine-5,5,5-d3 is an isotopic analogue of L-leucine.

Application

L-leucine-5,5,5-d3 is used in the quantitative determination of proteins using mass spectrometry and also used in the synthesis of (2S,4R)-(5,5,5-d3)leucine via stereospecific manner.
Used in the methodology of stable isotope tagging of epitopes (SITE) for identification of virus-induced peptides in vaccine development.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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25G
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MMYOMAG-74K-13

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Sigma-Aldrich

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Gerald W Becker
Briefings in functional genomics & proteomics, 7(5), 371-382 (2008-12-25)
Straightforward methods for the introduction of stable isotopes into proteins with subsequent isolation and purification of the proteins will greatly aid the field of quantitative proteomics. Proteins containing amino acids with one or more of the stable isotopes of deuterium
Hugo D Meiring et al.
Molecular & cellular proteomics : MCP, 5(5), 902-913 (2006-01-25)
Identification of peptides presented in major histocompatibility complex (MHC) class I molecules after viral infection is of strategic importance for vaccine development. Until recently, mass spectrometric identification of virus-induced peptides was based on comparative analysis of peptide pools isolated from

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