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490024

Sigma-Aldrich

L-Glutamine-(amide-15N)

98 atom % 15N

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Linear Formula:
H215NCO(CH2)2CH(NH2)CO2H
CAS Number:
Molecular Weight:
147.14
MDL number:
PubChem Substance ID:
NACRES:
NA.12

isotopic purity

98 atom % 15N

Quality Level

assay

99% (CP)

form

solid

optical activity

[α]25/D +33.0°, c = 2 in 5 M HCl

mp

185 °C (dec.) (lit.)

mass shift

M+1

SMILES string

N[C@@H](CCC([15NH2])=O)C(O)=O

InChI

1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1/i7+1

InChI key

ZDXPYRJPNDTMRX-QQKKVIQDSA-N

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1 of 4

This Item
605166486809607983
L-Glutamine-(amide-15N) 98 atom % 15N

490024

L-Glutamine-(amide-15N)

L-Glutamine-13C5 98 atom % 13C, 95% (CP)

605166

L-Glutamine-13C5

L-Glutamine-(amine-15N) 98 atom % 15N

486809

L-Glutamine-(amine-15N)

L-Glutamine-13C5,15N2 98 atom % 13C, 98 atom % 15N

607983

L-Glutamine-13C5,15N2

isotopic purity

98 atom % 15N

isotopic purity

98 atom % 13C

isotopic purity

98 atom % 15N

isotopic purity

98 atom % 13C, 98 atom % 15N

mass shift

M+1

mass shift

M+5

mass shift

M+1

mass shift

M+7

form

solid

form

solid

form

solid

form

solid

mp

185 °C (dec.) (lit.)

mp

185 °C (dec.) (lit.)

mp

185 °C (dec.) (lit.)

mp

185 °C (dec.) (lit.)

optical activity

[α]25/D +33.0°, c = 2 in 5 M HCl

optical activity

[α]25/D +33.0°, c = 2 in 5 M HCl

optical activity

[α]25/D +33.0°, c = 2 in 5 M HCl

optical activity

[α]25/D +33.0°, c = 2 in 5 M HCl

General description

L-Glutamine is a branched chain, non-essential amino acid. It is one of the most abundant amino acid found in central nervous system (CNS), plasma and human skeletal muscle.(2) L- Glutamine is synthesized by transamination of glutamate catalyzed by glutamine synthetase.

Biochem/physiol Actions

L-Glutamine, a source of nitrogen, mainly contributes to the synthesis of proteins, peptides, purine, pyrimidine, nucleotides, nucleic acids and major precursor of neurotransmitter. It acts as a fuel for the proliferation of lymphocytes and macrophages of immune system, for intestinal tissue to maintain gut integrity and for insulin production.(4)(3) L-Glutamine is released by skeletal muscle during stress conditions.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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25G
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705578-5MG-PW

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MMYOMAG-74K-13

1000309185

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Glutamine and glutamate as vital metabolites
Newsholme P, et al.
Brazilian journal of medical and biological research, 36(2), 153-163 (2003)
The influence of oral L-glutamine supplementation on muscle strength recovery and soreness following unilateral knee extension eccentric exercise
Legault Z, et al.
International Journal of Sport Nutrition and Exercise Metabolism, 25(5), 417-426 null
Katarzyna Dąbrowska et al.
Neurochemistry international, 118, 225-232 (2018-07-19)
SN1, a system N amino acid transporter specific for astrocytes, is mainly responsible for export of newly synthesized L-glutamine from the cells. Astrocytic retention of L-glutamine which plays a critical role in ammonia-induced astrocytic swelling resulting in brain edema, could
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Targeted tandem mass spectrometry (LC-MS/MS) has been extremely useful for profiling small molecules extracted from biological sources, such as cells, bodily fluids and tissues. Here, we present a protocol for analysing incorporation of the non-radioactive stable isotopes carbon-13 (13C) and

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