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492620

Sigma-Aldrich

Formaldehyde-d2 solution

~20 wt. % in D2O, 98 atom % D

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Synonym(s):
Deuterated formaldehyde, Formalin-d2
Linear Formula:
DCDO
CAS Number:
Molecular Weight:
32.04
MDL number:
PubChem Substance ID:
NACRES:
NA.12

isotopic purity

98 atom % D

concentration

~20 wt. % in D2O

technique(s)

protein expression: suitable

mass shift

M+2

SMILES string

[2H]C([2H])=O

InChI

1S/CH2O/c1-2/h1H2/i1D2

InChI key

WSFSSNUMVMOOMR-DICFDUPASA-N

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This Item
596388489417252549
Formaldehyde solution ACS reagent, 37 wt. % in H2O, contains 10-15% Methanol as stabilizer (to prevent polymerization)

Sigma-Aldrich

252549

Formaldehyde solution

concentration

~20 wt. % in D2O

concentration

20 wt. % in D2O

concentration

20 wt. % in H2O

concentration

36.5-38.0%, 37 wt. % in H2O

technique(s)

protein expression: suitable

technique(s)

protein expression: suitable

technique(s)

protein expression: suitable

technique(s)

-

mass shift

M+2

mass shift

M+3

mass shift

M+1

mass shift

-

General description

Formaldehyde-d2, isotopically labeled solution of formaldehyde.

Application

Formaldehyde-d2 solution is used in the synthesis of dimethylated peptides. It is also used in quantification of antigens in vaccine products.
Stable Isotope methyl labeling has led to quantification of antigens in influenza vaccine. It is also used in global antigen quantification of different types of protein-based vaccine and manufacturing intermediates.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Formaldehyde in Water

Jue-Liang Hsu et al.
Analytical chemistry, 75(24), 6843-6852 (2003-12-13)
In this paper, we report a novel, stable-isotope labeling strategy for quantitative proteomics that uses a simple reagent, formaldehyde, to globally label the N-terminus and epsilon-amino group of Lys through reductive amination. This labeling strategy produces peaks differing by 28
Kevin Colizza et al.
Journal of the American Society for Mass Spectrometry, 29(4), 675-684 (2018-01-27)
Our efforts to lower the detection limits of hexamethylene triperoxide diamine (HMTD) have uncovered previously unreported gas-phase reactions of primary and secondary amines with one of the six methylene carbons. The reaction occurs primarily in the atmospheric pressure chemical ionization
Chunli Wang et al.
Scientific reports, 6, 22645-22645 (2016-03-05)
Proteolysis is a major form of post translational modification which occurs when a protease cleaves peptide bonds in a target protein to modify its activity. Tracking protease substrates is indispensable for understanding its cellular functions. However, it is difficult to
Michelle D Gonsalves et al.
Xenobiotica; the fate of foreign compounds in biological systems, 51(4), 394-403 (2021-01-14)
Triacetone triperoxide (TATP) and hexamethylene triperoxide diamine (HMTD) are prominent explosive threats. Mitigation of peroxide explosives is a priority among the law enforcement community, with canine (K9) units being trained to recognise the scent of peroxide explosives. Herein, the metabolism
Sheng-Yu Huang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1104, 40-48 (2018-11-15)
Determining the precursor/product ion pair and optimal collision energy are the critical steps for developing a multiple reaction monitoring (MRM) assay using triple quadruple mass spectrometer for protein quantitation. In this study, a platform consisting of stable isotope dimethyl labeling

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