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493805

Sigma-Aldrich

5-(Ethylthio)-1H-tetrazole

95%

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Empirical Formula (Hill Notation):
C3H6N4S
CAS Number:
Molecular Weight:
130.17
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

95%

mp

84-90 °C (lit.)

storage temp.

2-8°C

SMILES string

CCSc1nnn[nH]1

InChI

1S/C3H6N4S/c1-2-8-3-4-6-7-5-3/h2H2,1H3,(H,4,5,6,7)

InChI key

GONFBOIJNUKKST-UHFFFAOYSA-N

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1 of 4

This Item
634573L030004L030000
ETT Activator 0.25 M in acetonitrile

Sigma-Aldrich

634573

ETT Activator

ETT Activator 0.25M

Sigma-Aldrich

L030004

ETT Activator

ETT Activator 0.25 M

Sigma-Aldrich

L030000

ETT Activator

mp

84-90 °C (lit.)

mp

-

mp

-

mp

-

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

-

General description

5-(Ethylthio)-1H-tetrazole (ETT) is an efficient activator, that activates nucleoside phosphoramidites towards condensation with a nucleoside to form dinucleoside phosphates during oligonucleotide synthesis.

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

Storage Class Code

4.1A - Other explosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Benzimidazolium Triflate as an Efficient Promoter for Nucleotide Synthesis via the Phosphoramidite Method.
Yoshihiro Hayakawa et al.
The Journal of organic chemistry, 61(23), 7996-7997 (1996-11-15)
An efficient method for the isolation and purification of oligoribonucleotides.
Sproat B, et al.
Nucleosides, nucleotides & nucleic acids, 14(1-2), 255-273 (1995)
Gregor S Cremosnik et al.
Angewandte Chemie (International ed. in English), 53(1), 286-289 (2013-11-14)
P-Amidites can be used in iterative couplings to selectively give mixed P(III) -P(V) anhydrides. These intermediates can be oxidized followed by a rapid removal of the two terminal fluorenylmethyl groups. An iterative synthesis (coupling, oxidation, deprotection) of nucleoside oligophosphates can

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