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MilliporeSigma

498203

Sigma-Aldrich

3,3,3-Trifluoropropionic acid

98%

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About This Item

Linear Formula:
CF3CH2CO2H
CAS Number:
2516-99-6
Molecular Weight:
128.05
MDL number:
MFCD00153292
UNSPSC Code:
12352100
PubChem Substance ID:
24873178
NACRES:
NA.22

Key Documents

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Quality Level

200

assay

98%

refractive index

n20/D 1.333 (lit.)

bp

145 °C/746 mmHg (lit.)

mp

9.7 °C (lit.)

density

1.45 g/mL at 25 °C (lit.)

functional group

carboxylic acid
fluoro

SMILES string

OC(=O)CC(F)(F)F

InChI

1S/C3H3F3O2/c4-3(5,6)1-2(7)8/h1H2,(H,7,8)

InChI key

KSNKQSPJFRQSEI-UHFFFAOYSA-N

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694401684686T75752
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assay

98%

assay

97%

assay

97%

assay

98%

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

bp

145 °C/746 mmHg (lit.)

bp

50-51 °C/15 mmHg

bp

25-30 °C/5 mmHg

bp

188-192 °C (lit.)

density

1.45 g/mL at 25 °C (lit.)

density

-

density

-

density

0.887 g/mL at 25 °C (lit.)

mp

9.7 °C (lit.)

mp

26-34 °C

mp

38-45 °C

mp

−10 °C (lit.)

refractive index

n20/D 1.333 (lit.)

refractive index

-

refractive index

-

refractive index

n20/D 1.445 (lit.)

Application

3,3,3-Trifluoropropionic acid may be used in the synthesis of:
  • 2,2,2-trifluoroethyl 3,3,3-trifluoroprionate[1]
  • ethyl 3,3,3-trifluoroprionate[1]
  • N-trifluoropropionyl-D-mannosamine[2]
  • 3,3,3-trifluoropropanoyl chloride[3]

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

198.0 °F - closed cup

flash_point_c

92.22 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN9537
BCCN2687
BCCJ8851
BCCH2103
BCCD1734

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157 nm Resist Materials: A Progress Report.
Chiba T, et al.
J. Photopolym. Sci. Technol., 13(4), 657-664 (2000)
Bifan Chen et al.
Analytical chemistry, 91(18), 11661-11669 (2019-08-24)
Antibody-drug conjugates (ADCs) are designed to combine the target specificity of monoclonal antibodies and potent cytotoxin drugs to achieve better therapeutic outcomes. Comprehensive evaluation of the quality attributes of ADCs is critical for drug development but remains challenging due to
Synthesis of ethyl 3,3,3-trifluoropropionate from 2-bromo-3,3,3-trifluoropropene.
Inoue M, et al.
Journal of Fluorine Chemistry, 167, 135-138 (2014)
Bi-phobic cellulose fibers derivatives via surface trifluoropropanoylation.
Cunha AG, et al.
Langmuir, 23(21), 10801-10806 (2007)
Yanbin Pan et al.
Carbohydrate research, 339(12), 2091-2100 (2004-07-29)
N-Acetyl-D-neuraminic acid (NeuNAc) aldolase is an important enzyme for the metabolic engineering of cell-surface NeuNAc using chemically modified D-mannosamines. To explore the optimal substrates for this application, eight N-acyl derivatives of D-mannosamine were prepared, and their accessibility to NeuNAc aldolase
View All Related Papers

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