531316

N-(tert-Butoxycarbonyl)-2-bromoaniline

97%

• Linear Formula: BrC₆H₄HNCO₂C(CH₃)₃
• CAS Number: 78839-75-5
• Molecular Weight: 272.14
• NACRES: NA.22
• PubChem Substance ID: 24877811
• UNSPSC Code: 12352100
• MDL number: MFCD01006614
• Assay: 97%

Properties

• InChI: 1S/C11H14BrNO2/c1-11(2,3)15-10(14)13-9-7-5-4-6-8(9)12/h4-7H,1-3H3,(H,13,14)
• SMILES string: CC(C)(C)OC(=O)Nc1ccccc1Br
• InChI key: UQBGKDLSIIHUEZ-UHFFFAOYSA-N
• assay: 97%
• refractive index: n20/D 1.54 (lit.)
• bp: 110 °C/0.3 mmHg (lit.)
• density: 1.342 g/mL at 25 °C (lit.)
• functional group: amine, bromo
• Quality Level: 100

Description

General description

N-(tert-Butoxycarbonyl)-2-bromoaniline, also known as tert-butyl-N-(2-bromophenyl)carbamate, is an N-Boc-protected o-bromoaniline.1 It reacts with ethyl perfluorooctanoate in the presence of tert-butyllithium to form the corresponding 1-hydroxy-1H-perfluorooctyl compound.[1]

Application

N-(tert-Butoxycarbonyl)-2-bromoaniline may be used in the synthesis of N-boc-protected o-aryl anilines, which undergoes coupling reaction with bromoacetylenes to form the corresponding arene?ynamides.[2]

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: 230.0 °F - closed cup
• flash_point_c: 110 °C - closed cup
• ppe: dust mask type N95 (US), Eyeshields, Gloves