548693

Sigma-Aldrich

5-Chloro-2-fluorobenzonitrile

97%

Linear Formula:
ClC6H3(F)CN
CAS Number:
Molecular Weight:
155.56
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

97%

mp

67-70 °C (lit.)

SMILES string

Fc1ccc(Cl)cc1C#N

InChI

1S/C7H3ClFN/c8-6-1-2-7(9)5(3-6)4-10/h1-3H

InChI key

GJNJDELEHIGPKJ-UHFFFAOYSA-N

General description

5-Chloro-2-fluorobenzonitrile is a benzonitrile derivative. The X-ray diffraction analysis indicates that its crystals belong to the monoclinic crystal system and P21/c space group.
5-Chloro-2-fluorobenzonitrile may be used in the preparation of methyl 3-amino-5-chlorobenzo[b]thiophene-2-carboxylate by reacting with methyl thioglycolate and triethylamine via microwave-assisted synthesis.

Packaging

1, 5 g in glass bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Analysis of Small Molecule X-Ray Crystal Structures: Chemical Crystallography with Undergraduate Students in a Teaching Laboratory.
Aldeborgh H, et al.
Journal of Chemical Crystallography, 44(2), 70-81 (2014)
Mark C Bagley et al.
Organic & biomolecular chemistry, 13(24), 6814-6824 (2015-05-28)
Microwave irradiation of 2-halobenzonitriles and methyl thioglycolate in the presence of triethylamine in DMSO at 130 °C provides rapid access to 3-aminobenzo[b]thiophenes in 58-96% yield. This transformation has been applied in the synthesis of the thieno[2,3-b]pyridine core motif of LIMK1...

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