555428

Sigma-Aldrich

2,5-Difluorobenzenesulfonyl chloride

97%

Linear Formula:
F2C6H3SO2Cl
CAS Number:
Molecular Weight:
212.60
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

97%

refractive index

n20/D 1.516 (lit.)

bp

221 °C (lit.)

density

1.58 g/mL at 25 °C (lit.)

SMILES string

Fc1ccc(F)c(c1)S(Cl)(=O)=O

InChI

1S/C6H3ClF2O2S/c7-12(10,11)6-3-4(8)1-2-5(6)9/h1-3H

InChI key

CELLJWUVMKEJDY-UHFFFAOYSA-N

General description

2,5-Difluorobenzenesulfonyl chloride participates in the synthesis of aryl sulfonamide-based mineralocorticoid receptor (MR) antagonists.

Packaging

1, 5 g in glass bottle

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Precautionary Statements

hazcat

Skin Corr. 1B

storage_class_code

8A - Combustible, corrosive hazardous materials

WGK Germany

WGK 3

Flash Point(F)

230.0 °F - closed cup

Flash Point(C)

110 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Kentaro Futatsugi et al.
Bioorganic & medicinal chemistry letters, 23(23), 6239-6242 (2013-10-26)
Hit-to-lead medicinal chemistry efforts are described starting from a screening hit 1, leading to a new class of aryl sulfonamide-based MR antagonist, exemplified by 17, that possesses favourable MR binding affinity, selectivity profile against closely related NHRs, physicochemical properties and...

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