561037

3,4-Difluorophenylmagnesium bromide solution

0.5 M in THF

• Linear Formula: F₂C₆H₃MgBr
• CAS Number: 90897-92-0
• Molecular Weight: 217.29
• MDL number: MFCD00672004
• PubChem Substance ID: 24879910
• NACRES: NA.22

Properties

• reaction suitability: reaction type: Grignard Reaction
• Quality Level: 100
• concentration: 0.5 M in THF
• bp: 65 °C
• density: 0.965 g/mL at 25 °C
• storage temp.: 2-8°C
• SMILES string: Fc1ccc([Mg]Br)cc1F
• InChI: 1S/C6H3F2.BrH.Mg/c7-5-3-1-2-4-6(5)8;;/h1,3-4H;1H;/q;;+1/p-1
• InChI key: WZHAVYGMKGPNFN-UHFFFAOYSA-M

Description

Application

3,4-Difluorophenylmagnesium bromide can be used:

• To prepare 3,4-difluorophenylboronic acid, a key building block employed in the synthesis of norepinephrine transporter selective molecules.
• In the synthesis of trimethoxybenzophenone derived tubulin polymerization inhibitors.
• In one of the key synthetic steps for the preparation of diarylketoxime derivatives as potent MCH-1R antagonists.
• In the synthesis of biologically important hydroxybupropion analogs useful in smoking cessation.

Legal Information

Product of Rieke Metals, Inc.
Rieke is a registered trademark of Rieke Metals, Inc.

Safety Information

• Pictograms: GHS02,GHS07,GHS08
• Signal Word: Danger
• Hazard Statements: H225 - H302 - H319 - H335 - H351
• Precautionary Statements: P210 - P280 - P301 + P312 + P330 - P305 + P351 + P338 - P370 + P378 - P403 + P235
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• Target Organs: Respiratory system
• Supplementary Hazards: EUH019
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 1.0 °F - closed cup
• Flash Point(C): -17.2 °C - closed cup