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56485

Sigma-Aldrich

N-Hydroxysulfosuccinimide sodium salt

≥98% (HPLC)

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Synonym(s):
Hydroxy-2,5-dioxopyrrolidine-3-sulfonicacid sodium salt, Sulfo-NHS
Empirical Formula (Hill Notation):
C4H4NNaO6S
CAS Number:
106627-54-7
Molecular Weight:
217.13
Beilstein:
6359129
MDL number:
MFCD00043100
PubChem Substance ID:
57651582
NACRES:
NA.22

Quality Level

200

Assay

≥98% (HPLC)

form

powder

composition

carbon, 21.57-22.68 (anhydrous)
nitrogen, 6.28-6.61 (anhydrous)

reaction suitability

reaction type: Addition Reactions

impurities

≤4% water

application(s)

peptide synthesis

SMILES string

[Na+].ON1C(=O)CC(C1=O)S([O-])(=O)=O

InChI

1S/C4H5NO6S.Na/c6-3-1-2(12(9,10)11)4(7)5(3)8;/h2,8H,1H2,(H,9,10,11);/q;+1/p-1

InChI key

RPENMORRBUTCPR-UHFFFAOYSA-M

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This Item
56480130672SML2148
N-Hydroxysulfosuccinimide sodium salt ≥98% (HPLC)

Sigma-Aldrich

56485

N-Hydroxysulfosuccinimide sodium salt

N-Hydroxysuccinimide purum, ≥97.0% (T)

Sigma-Aldrich

56480

N-Hydroxysuccinimide

N-Hydroxysuccinimide 98%

Sigma-Aldrich

130672

N-Hydroxysuccinimide

Sulfo-N-succinimidyl Oleate sodium ≥95% (HPLC)

Sigma-Aldrich

SML2148

Sulfo-N-succinimidyl Oleate sodium

form

powder

form

solid

form

solid

form

powder

impurities

≤4% water

impurities

-

impurities

-

impurities

-

composition

carbon, 21.57-22.68 (anhydrous)

composition

-

composition

-

composition

-

reaction suitability

reaction type: Addition Reactions

reaction suitability

reaction type: Addition Reactions

reaction suitability

-

reaction suitability

-

application(s)

peptide synthesis

application(s)

peptide synthesis

application(s)

-

application(s)

-

Application

N-Hydroxysulfosuccinimide sodium salt is a water-soluble sulfonated analog of N-hydroxysuccinimide. It can undergo a coupling reaction with carboxylic acids in the presence of carbodiimides such as 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide(EDC) to form hydrophilic N-hydroxysulfosuccinimide active esters. These esters are useful in protein cross-linking experiments.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Sulfo-NHS is used for preparing hydrophilic active esters, e.g. for crosslinking agents

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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International journal of peptide and protein research, 30(1), 117-124 (1987-07-01)
N-Hydroxysulfosuccinimide esters are reactive functional groups employed in a variety of protein modification reagents, especially cross-linking reagents. For these compounds, hydrolysis is the most important reaction competing for reaction of the esters with nucleophilic groups in proteins. We have employed
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