607851

Sigma-Aldrich

L-Glutamic acid-13C5,15N

98 atom % 13C, 98 atom % 15N, 95% (CP)

Synonym(s):
13C and 15N Labeled L-glutamic acid, Glu-13C5,15N, (S)-2-Aminopentanedioic acid-13C5,15N
Linear Formula:
HO213C(13CH2)213CH(15NH2)13CO2H
CAS Number:
Molecular Weight:
153.09
MDL number:
PubChem Substance ID:
NACRES:
NA.12

isotopic purity

98 atom % 13C
98 atom % 15N

Quality Level

assay

95% (CP)

optical activity

[α]25/D +31.0°, c = 2 in 5 M HCl

application(s)

bio NMR: suitable

mp

205 °C (dec.) (lit.)

mass shift

M+6

SMILES string

[15NH2][13C@@H]([13CH2][13CH2][13C](O)=O)[13C](O)=O

InChI

1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1/i1+1,2+1,3+1,4+1,5+1,6+1

InChI key

WHUUTDBJXJRKMK-UFLWJPECSA-N

Related Categories

General description

Glutamic acid is an amino acid with an acidic side group. It works as a proton donor. Decarboxylation of glutamic acid results in the formation of GABA (γ aminobutyric acid), a potent neurotransmitter. Isotope labeled amino acids are required for the production of isotopically labeled proteins.

Packaging

1 g in glass bottle
250 mg in glass bottle
This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Kishore K Mahalingan et al.
Nature structural & molecular biology, 27(9), 802-813 (2020-08-05)
Glutamylation, introduced by tubulin tyrosine ligase-like (TTLL) enzymes, is the most abundant modification of brain tubulin. Essential effector proteins read the tubulin glutamylation pattern, and its misregulation causes neurodegeneration. TTLL glutamylases post-translationally add glutamates to internal glutamates in tubulin carboxy-terminal...
Fumihiro Eto et al.
Scientific reports, 10(1), 7435-7435 (2020-05-06)
The brain consists of various areas with anatomical features. Neurons communicate with one another via excitatory or inhibitory synaptic transmission. Altered abundance of neurotransmitters, including glutamate and gamma-aminobutyric acid (GABA), in specific brain regions is closely involved in severe neurological...
Harvey RA, et al.
Biochemistry (Lippincott's illustrated reviews) (2011)
Isotope labeling for solution and solid-state NMR spectroscopy of membrane proteins.
Verardi R, et al.
Advances in Experimental Medicine and Biology, 992, 35-62 (2012)
Incorporation of radioactive amino acids into proteins of the microsome fraction of guinea-pig liver in a cell-free system.
SIMKIN JL and WORK TS
The Biochemical Journal, 67, 617-624 (1957)

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