608092

Sigma-Aldrich

L-Isoleucine-13C6,15N

98 atom % 13C, 98 atom % 15N, 95% (CP)

Synonym(s):
SILAC Amino Acid, 13C and 15N Labeled L-isoleucine, (2S,3S)-2-Amino-3-methylpentanoic acid-13C6,15N
Linear Formula:
13C2H513CH(13CH3)13CH(15NH2)13CO2H
CAS Number:
Molecular Weight:
138.12
MDL number:
PubChem Substance ID:
NACRES:
NA.12

Quality Level

isotopic purity

98 atom % 13C
98 atom % 15N

assay

95% (CP)

optical activity

[α]25/D +40.0°, c = 2 in 5 M HCl

application(s)

bio NMR: suitable
protein expression: suitable

mp

168-170 °C (lit.)

mass shift

M+7

SMILES string

[13CH3][13CH]([13CH3])[13CH2][13C@H]([15NH2])[13C](O)=O

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1/i1+1,2+1,3+1,4+1,5+1,6+1,7+1

InChI key

ROHFNLRQFUQHCH-HUEJSTCGSA-N

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General description

L-isoleucine is an essential amino acid that is synthesized from threonine. It is a branched-chain hydrophobic amino acid. L-isoleucine is an isomer of L-leucine.

Application

L-Isoleucine-13C6,15N is used in the immunocapture isotope dilution mass spectrometry (IC-IDMS) to evaluate the suitability of the underlying monoclonal andpolyclonal antibodies (mAbs and pAbs) for new vaccine quantification.

Packaging

100 mg in glass bottle
This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Carrie L Pierce et al.
Vaccine, 35(37), 5011-5018 (2017-08-05)
As a result of recent advances in mass spectrometry-based protein quantitation methods, these techniques are now poised to play a critical role in rapid formulation of pandemic influenza vaccines. Analytical techniques that have been developed and validated on seasonal influenza...

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