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638072

Sigma-Aldrich

SPhos

greener alternative

98%

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Synonym(s):
SPhos, 2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl, S Phos
Empirical Formula (Hill Notation):
C26H35O2P
CAS Number:
Molecular Weight:
410.53
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

98%

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Cross Couplings
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction

reagent type: ligand
reaction type: Heck Reaction

reagent type: ligand
reaction type: Kumada Coupling

reagent type: ligand
reaction type: Negishi Coupling

reagent type: ligand
reaction type: Suzuki-Miyaura Coupling

greener alternative product score

old score: 10
new score: 1
Find out more about DOZN™ Scoring

greener alternative product characteristics

Waste Prevention
Less Hazardous Chemical Syntheses
Inherently Safer Chemistry for Accident Prevention
Learn more about the Principles of Green Chemistry.

mp

164-166 °C (lit.)

functional group

phosphine

greener alternative category

SMILES string

COc1cccc(OC)c1-c2ccccc2P(C3CCCCC3)C4CCCCC4

InChI

1S/C26H35O2P/c1-27-23-17-11-18-24(28-2)26(23)22-16-9-10-19-25(22)29(20-12-5-3-6-13-20)21-14-7-4-8-15-21/h9-11,16-21H,3-8,12-15H2,1-2H3

InChI key

VNFWTIYUKDMAOP-UHFFFAOYSA-N

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This Item
901906675784638080
SPhos 98%

638072

SPhos

SPhos 95%

901906

SPhos

tBuXPhos 98%

638080

tBuXPhos

assay

98%

assay

95%

assay

-

assay

98%

functional group

phosphine

functional group

phosphine

functional group

phosphine

functional group

phosphine

Quality Level

300

Quality Level

-

Quality Level

-

Quality Level

300

mp

164-166 °C (lit.)

mp

164-166 °C (lit.), 165.5 °C

mp

211-219 °C

mp

148-151 °C (lit.)

greener alternative product score

old score: 10
new score: 1
Find out more about DOZN™ Scoring

greener alternative product score

-

greener alternative product score

-

greener alternative product score

old score: 12
new score: 1
Find out more about DOZN™ Scoring

General description

SPhos [2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.
We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Less Hazardous Chemical Syntheses” and “Inherently Safer Chemistry for Accident Prevention”. Click here to view its DOZN scorecard.

Application

Learn more about Buchwald Phosphine Ligands

For small scale and high throughput uses, product is also available as ChemBeads (932191)
SPhos may be used as a ligand in the following processes:
  • Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between Boc-protected aminomethyltrifluoroborate and aryl chlorides or hetaryl chlorides to form the corresponding aminomethylarenes.
  • Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between 4-methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines.
  • Intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C.
Utilized in conjunction with palladium to form a highly active catalyst for C-N bond formation.
Highly universal ligand for Suzuki-Miyaura coupling; aryl chlorides, hindered biaryls, heterobiaryls.

Legal Information

Usage subject to Patents: US 6307087; EP 1097158; JP 5758844; CA 2336691

related product

Product No.
Description
Pricing

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Fast Pd-and Pd/Cu-Catalyzed Direct C?H Arylation of Cyclic Nitrones. Application to the Synthesis of Enantiopure Quaternary ?-Amino Esters
Demory, Emilien, et al.
The Journal of Organic Chemistry, 77.18, 7901-7912 (2012)
A general solution for unstable boronic acids: slow-release cross-coupling from air-stable MIDA boronates
Knapp, David M., Eric P. Gillis, and Martin D. Burke
Journal of the American Chemical Society, 131.20, 6961-6963 (2009)
Pd-catalyzed Suzuki?Miyaura reactions of aryl halides using bulky biarylmonophosphine ligands
Altman, Ryan A., and Stephen L. Buchwald
Nature Protocols, 2.12 (2007)
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Handa, Sachin, et al.
Science, 349.6252, 1087-1091 (2015)
Pd-catalyzed Kumada-Corriu cross-coupling reactions at low temperatures allow the use of Knochel-type Grignard reagents.
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Journal of the American Chemical Society, 129(13), 3844-3845 (2007-03-14)

Articles

Buchwald Phosphine Ligands

Buchwald phosphine ligands for C-C, C-N, and C-O bond formation.

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