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638439
JohnPhos
97%
Synonym(s):
(2-Biphenyl)di-tert-butylphosphine, (2-Biphenylyl)di-tert-butylphosphine, 2-(Di-tert-butylphosphino)biphenyl
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$67.30
$320.00
$811.00
$67.30
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About This Item
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assay
97%
reaction suitability
reaction type: Cross Couplings, reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction, reagent type: ligand
reaction type: C-X Bond Formation, reagent type: ligand
reaction type: Heck Reaction, reagent type: ligand
reaction type: Suzuki-Miyaura Coupling
mp
86-88 °C (lit.)
functional group
phosphine
Quality Level
Related Categories
1 of 4
This Item | 638099 | 695874 | 675938 |
|---|---|---|---|
| assay 97% | assay 97% | assay - | assay 96% |
| reaction suitability reaction type: Cross Couplings, reagent type: ligand | reaction suitability reaction type: Cross Couplings, reagent type: ligand | reaction suitability - | reaction suitability reaction type: Cross Couplings, reagent type: ligand |
| functional group phosphine | functional group phosphine | functional group phosphine | functional group phosphine |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| mp 86-88 °C (lit.) | mp 102-106 °C (lit.) | mp 114-118 °C | mp 168-172 °C |
General description
Learn more about Buchwald Phosphine Ligands
Application
- Hydrophenoxylation of unactivated internal alkynes.[4]
- Microwave-mediated Suzuki-Miyaura cross-coupling of benzylic bromides.[5]
- Pharmaceutical synthesis of novel imidazo[1,2-a]pyridines, having potent activity against the herpes virus.[6]
- Barluenga′s coupling of vinyl bromides with hydrazines.[6]
- Pd-catalyzed 2,3-diarylation of α,α-disubstituted-3-thiophenemethanols, via cleavage of C-H and C-C bonds.[7]
Catalyst for:
- Decarboxylative cross-coupling of dialkoxybenzoic acids with diaryl disulfides or diaryl diselenides
- Stereoselective preparation of imidazolidinones via intramolecular hydroamination of N-allylic-N-arylureas
- Regioselective arylation of olefins with aryl chlorides
- Cross-coupling reaction for the synthesis of polyunsaturated macrolactones
- Regioselective O-alkylation reactions
- Sonogashira-type cross coupling
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Articles
Buchwald phosphine ligands for C-C, C-N, and C-O bond formation.
Buchwald and coworkers develop versatile phosphine ligands for Pd-catalyzed C–N bond formation; enhancing synthetic reactions for 20 years.
Buchwald phosphine ligands for C-C, C-N, and C-O bond formation.
Buchwald Phosphine Ligands
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The Catalexis platform enhances catalysis by digitally optimizing catalyst selection to identify the most effective phosphine ligands for cross-coupling reactions.
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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