651753

2-Chloro-5-fluoropyrimidine

97%

• Empirical Formula (Hill Notation): C₄H₂ClFN₂
• CAS Number: 62802-42-0
• Molecular Weight: 132.52
• MDL number: MFCD03788197
• UNSPSC Code: 12352100
• PubChem Substance ID: 24883860
• NACRES: NA.22

Properties

• assay: 97%
• refractive index: n20/D 1.503 (lit.)
• density: 1.439 g/mL at 20 °C (lit.)
• functional group: chloro; fluoro
• SMILES string: Fc1cnc(Cl)nc1
• InChI: 1S/C4H2ClFN2/c5-4-7-1-3(6)2-8-4/h1-2H
• InChI key: AGYUQBNABXVWMS-UHFFFAOYSA-N

Description

Application

2-Chloro-5-fluoropyrimidine can be used as a starting material for the preparation of:

• 5-fluoro-2-amino pyrimidines by reacting with various amines in the presence of K₂CO₃, via C-N bond forming reaction.[1]
• 2-chloro-5-(5-fluoropyrimidin-2-yl)benzoic acid, an intermediate, which is used in the synthesis of benzamide scaffolds as potent antagonists against P2X7 receptors.[2]
• 5-fluoro-2-cyano pyrimidine, a key intermediate used for the synthesis of 5-chloro-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine, as a potent inhibitor of the JAK2 kinase.[3]

Safety Information

• pictograms: GHS05,GHS07
• signalword: Danger
• hcodes: H302,H314
• pcodes: P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Acute Tox. 4 Oral - Skin Corr. 1B
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 3
• flash_point_f: 149.0 °F - closed cup
• flash_point_c: 65 °C - closed cup
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter