663190
Ethyl 5-methylindole-2-carboxylate
97%
Synonym(s):
5-Methylindole-2-carboxylic acid ethyl ester, NSC 30928
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 g | Check Cart for Availability | $116.00 |
About This Item
Empirical Formula (Hill Notation):
C12H13NO2
CAS Number:
Molecular Weight:
203.24
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
97%
Form:
solid
Quality Level
assay
97%
form
solid
mp
160-164 °C
functional group
ester
SMILES string
CCOC(=O)c1cc2cc(C)ccc2[nH]1
InChI
1S/C12H13NO2/c1-3-15-12(14)11-7-9-6-8(2)4-5-10(9)13-11/h4-7,13H,3H2,1-2H3
InChI key
KMVFKXFOPNKHEM-UHFFFAOYSA-N
General description
Ethyl 5-methylindole-2-carboxylate (5-Methylindole-2-carboxylic acid ethyl ester) is an indole derivative. Indole ring system is an important building block or intermediate in the synthesis of many pharmaceutical agents. It is formed during the Fischer indolization of ethyl pyruvate 2-[2-(methanesulfonyloxy)-4-methyl]phenylhydrazine.
Application
- Reactant for synthesis of oxazino[4,3-a]indoles via cascade addition-cyclization reactions
- Reactant for preparation of indolecarboxamides as cannabinoid CB1 receptor antagonists
- Reactant for preparation of indole-3-propionic acids as antiinflammatory and analgesic agents
- Reactant for Friedel-Crafts acylation with nitrobenzoyl chloride
- Reactant for oximation reactions
1 of 1
This Item | ||
|---|---|---|
| assay 97% | assay 99% | assay 96% |
| Quality Level 100 | Quality Level 100 | Quality Level 100 |
| mp 160-164 °C | mp 126-128 °C (lit.) | mp - |
| form solid | form - | form solid |
| functional group ester | functional group ester | functional group bromo, ester |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Articles
Friedel-Crafts acylation with Lewis acid catalysts forms monoacylated products via electrophilic aromatic substitution of arenes.
Substituent Effects in the Fischer Indolization of (2-Sulfonyloxyphenyl) hydrazones (Fischer Indolization and Related Compounds. XXX).
Murakami Y, et al.
Chemical & Pharmaceutical Bulletin, 47, 791-797 (1999)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 663190-5G | 04061832842028 |
| 663190-1G | 04061826138137 |