663557

Sigma-Aldrich

2-Amino-5-(4-fluorophenyl)-1,3,4-thiadiazole

97%

Synonym(s):
5-(4-Fluorophenyl)-1,3,4-thiadiazol-2-amine
Empirical Formula (Hill Notation):
C8H6FN3S
CAS Number:
Molecular Weight:
195.22
MDL number:
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

assay

97%

mp

238-243 °C

SMILES string

Nc1nnc(s1)-c2ccc(F)cc2

InChI

1S/C8H6FN3S/c9-6-3-1-5(2-4-6)7-11-12-8(10)13-7/h1-4H,(H2,10,12)

InChI key

WRSVCKNLHZWSNJ-UHFFFAOYSA-N

Application

2-Amino-5-(4-fluorophenyl)-1,3,4-thiadiazole can be used as a substrate in the preparation of:
  • Bithiophene based azo dyes with possible nonlinear optical (NLO) properties.
  • 4-Thiazolidinone derivatives as potent HCV NS5B polymerase inhibitors.
  • 1,3,4-Thiadiazole and phenothiazine hybrids as possible antitubercular agents.

Packaging

1, 5 g in glass bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

Xn

Risk Statement

22-36

Safety Statement

26

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Design of new phenothiazine-thiadiazole hybrids via molecular hybridization approach for the development of potent antitubercular agents
Ramprasad J, et al.
European Journal of Medicinal Chemistry, 106(2), 75-84 (2015)
2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase
Kucukguzel ?, et al.
European Journal of Medicinal Chemistry, 69(2), 931-941 (2013)
Design, synthesis and evaluation of redox, second order nonlinear optical properties and theoretical DFT studies of novel bithiophene azo dyes functionalized with thiadiazole acceptor groups
Castro MR, et al.
Dyes and Pigments, 95(2), 392-399 (2012)

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