675075

8-Mercaptooctanoic acid

95%

• Synonym(s): 8-Thiooctanoic acid, MOA
• Empirical Formula (Hill Notation): C₈H₁₆O₂S
• CAS Number: 74328-61-3
• Molecular Weight: 176.28
• MDL number: MFCD08705279
• UNSPSC Code: 12352103
• PubChem Substance ID: 24885256
• NACRES: NA.23

Properties

• Quality Level: 100
• assay: 95%
• refractive index: n20/D 1.4808
• density: 1.0326 g/mL at 25 °C
• storage temp.: −20°C
• SMILES string: OC(=O)CCCCCCCS
• InChI: 1S/C8H16O2S/c9-8(10)6-4-2-1-3-5-7-11/h11H,1-7H2,(H,9,10)
• InChI key: FYEMIKRWWMYBFG-UHFFFAOYSA-N

Description

General description

8-Mercaptooctanoic acid (MOA) is an carboxylic acid terminated alkanethiol that forms self-assembled monolayers (SAMs) that facilitate subsequent surface immobilization of other molecular species.[1]

8-mercaptooctanoic acid (MOA) forms a self-assembled monolayer (SAM) on the surface of nanoparticles. MOA consists of thiol and carboxylic groups which helps in the surface treatment of different nanoparticles.[2][3]

Application

MOA is a used as a SAM for surface modification of gold electrodes for quartz crystal microbalance (QCMB) measurement.[2] It may be used as a monolayer that facilitates ferritin absorption on gold electrodes for uptake of excess iron in the cell.[3] It may also be used for preparation of nitric oxide based gold nanoparticles (NO-AuNPs) for macrophage photo-thermal therapy under NIR irradiation.[4]

MOA may form SAM that can be used in the surface modification of gold electrodes which are useful for the study of surface characteristics of ferritin.[3] It may also be used to form SAM with hydrophilic end groups to be used as a protective coating on the electrodes for efficient electron transport in semiconductor devices.[5]

This compound is used to produce hydrophilic SAMs. The resulting monolayers which are terminated with carboxylic acids can be further functionalized[6] to introduce more complex end groups. Can also be used to form a protective barrier monolayer to allow deposition of a passivating oxide layer.[7]

Other Notes

This product should be stored in the freezer, 0 to -20 °C

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type ABEK (EN14387) respirator filter