(R,R)-(-)-2,3-Bis(tert-butylmethylphosphino)quinoxaline is an air-stable C2-symmetric P-stereogenic phosphine ligand.
Efficient ligand exhibiting high levels of enantiocontrol in synthetic transformations ranging from metal-catalyzed 1,4-addition of arylboronic acids to alkylative ring opening to asymmetric hydrogenation.
100 mg in clear glass bottle
500 mg in amber glass bottle
Features and Benefits
Advantages of the QuinoxP* Ligands:
- It is not oxidized nor epimerized at ambient conditions in air
- Enantioselectivities are outstanding for various reaction paradigms
- Hydrogenations proceed under mild reaction conditions
- Low catalyst loadings yield high TONs
Yahav-Levi A, et al. "Aryl-bromide reductive elimination from an isolated Pt (IV) complex." Chemical Communications 46(19) (2010): 3324-3326.
Fang P and Hou XL. "Asymmetric Copper-Catalyzed Propargylic Substitution Reaction of Propargylic Acetates with Enamines." Organic letters 11.20 (2009): 4612-4615.
Imamoto T, et al. "Highly enantioselective hydrosilylation of simple ketones catalyzed by rhodium complexes of P-chiral diphosphine ligands bearing tert-butylmethylphosphino groups." Tetrahedron: Asymmetry 17(4) (2006): 560-565.
QuinoxP is a registered trademark of Nippon Chemical Industry Co., Ltd.