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690481

Sigma-Aldrich

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8a,9S)-6′-methoxy-9-cinchonanyl]thiourea

90%

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Synonym(s):
1-[3,5-Bis(trifluoromethyl)phenyl)-3-{(S)(6-methoxy-4-quinolinyl)-[(2S,4S,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl]methyl}thiourea, epi-N-Quinyl-N′-bis(3,5-trifluoromethyl)phenylthiourea
Empirical Formula (Hill Notation):
C29H28F6N4OS
CAS Number:
852913-16-7
Molecular Weight:
594.61
MDL number:
MFCD16875670
UNSPSC Code:
12352005
PubChem Substance ID:
329761344
NACRES:
NA.22

Quality Level

100

assay

≥89.0%
90%

form

lumps

SMILES string

COc1ccc2nccc([C@H](NC(=S)Nc3cc(cc(c3)C(F)(F)F)C(F)(F)F)C4CC5CCN4C[C@@H]5C=C)c2c1

InChI

1S/C29H28F6N4OS/c1-3-16-15-39-9-7-17(16)10-25(39)26(22-6-8-36-24-5-4-21(40-2)14-23(22)24)38-27(41)37-20-12-18(28(30,31)32)11-19(13-20)29(33,34)35/h3-6,8,11-14,16-17,25-26H,1,7,9-10,15H2,2H3,(H2,37,38,41)/t16-,17-,25-,26-/m0/s1

InChI key

IQMKPBFOEWWDIQ-FRSFCCSCSA-N

Related Categories

Application

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8a,9S)-6′-methoxy-9-cinchonanyl]thiourea is a bifunctional cinchona organocatalyst, which can be used to synthesize:
  • Stereoselective diaryl(nitro)butanone via enantioselective Michael addition of nitromethane to chalcones.
  • Enantioselective β-amino acids via asymmetric Mannich reaction of malonates with aryl and alkyl imines.
  • The synthesis of 3-indolylmethanamines by the reaction of indoles with imines via asymmetric Friedel-Crafts reaction.
  • The enantioselective conjugate addition of active methylene compounds to enones to obtain the corresponding addition products.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificates of Analysis (COA)

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The Mannich reaction of malonates with simple imines catalyzed by bifunctional cinchona alkaloids: enantioselective synthesis of ?-amino acids
Song J, et al.
Journal of the American Chemical Society, 128(18), 6048-6049 (2006)
Asymmetric Friedel- Crafts reaction of indoles with imines by an organic catalyst
Wang Y-Q, et al.
Journal of the American Chemical Society, 128(25), 8156-8157 (2006)
Organocatalytic enantioselective conjugate additions to enones
Wang J, et al.
Journal of the American Chemical Society, 128(39), 12652-12653 (2006)
Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts
Vakulya B, et al.
Organic Letters, 7(10), 1967-1969 (2005)
Urea- and thiourea-substituted cinchona alkaloid derivatives as highly efficient bifunctional organocatalysts for the asymmetric addition of malonate to nitroalkenes: inversion of configuration at C9 dramatically improves catalyst performance.
Séamus H McCooey et al.
Angewandte Chemie (International ed. in English), 44(39), 6367-6370 (2005-09-02)
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