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2,2,6-Trimethyl-4H-1,3-dioxin-4-one

Arxada quality, ≥93.0% (GC)

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Synonym(s):
TMD, Diketene acetone adduct
Empirical Formula (Hill Notation):
C7H10O3
CAS Number:
Molecular Weight:
142.15
Beilstein:
2408
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

≥93.0% (GC)

form

liquid

quality

Arxada quality

manufacturer/tradename

Arxada AG

impurities

≤0.10% diketene (GC)
≤0.4% dehydracetic acid (GC)
≤0.5% 4-methyl-3-penten-2-one (GC)
≤6.0% acetone (GC)

refractive index

n20/D 1.460 (lit.)

bp

~275 °C (lit.)
65-67 °C/2 mmHg (lit.)

mp

12-13 °C (lit.)

solubility

H2O: insoluble

density

1.07 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

CC1=CC(=O)OC(C)(C)O1

InChI

1S/C7H10O3/c1-5-4-6(8)10-7(2,3)9-5/h4H,1-3H3

InChI key

XFRBXZCBOYNMJP-UHFFFAOYSA-N

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This Item
24510087718127604
Tetramethylammonium chloride BioUltra, for molecular biology, ≥99.0% (AT)

Sigma-Aldrich

87718

Tetramethylammonium chloride

Premium Grade
3-Pentanone ReagentPlus®, ≥99.0% (GC)

Sigma-Aldrich

127604

3-Pentanone

-
form

liquid

form

liquid

form

crystals

form

liquid

refractive index

n20/D 1.460 (lit.)

refractive index

n20/D 1.460 (lit.)

refractive index

-

refractive index

n20/D 1.392 (lit.)

bp

~275 °C (lit.), 65-67 °C/2 mmHg (lit.)

bp

~275 °C (lit.), 65-67 °C/2 mmHg (lit.)

bp

-

bp

101.5 °C (lit.)

mp

12-13 °C (lit.)

mp

12-13 °C (lit.)

mp

>300 °C (lit.)

mp

−42 °C (lit.)

solubility

H2O: insoluble

solubility

water: insoluble

solubility

H2O: 6 M at 20 °C, clear, colorless

solubility

water: slightly soluble

Application

2,2,6-Trimethyl-4H-1,3-dioxin-4-one is generally used as a reactant for the synthesis of acetoacetic esters from aliphatic as well as aromatic alcohols. It can also acetoacetylate amines and thiols.

Caution

products darkens with time

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

57.2 °F - closed cup

Flash Point(C)

14 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Synthesis and biological evaluation of some new 1, 4-dihydropyridines containing different ester substitute and diethyl carbamoyl group as anti-tubercular agents
Khoshneviszadeh M, et al.
Bioorganic & Medicinal Chemistry, 17(4), 1579-1586 (2009)
Synthesis, study of 3D structures, and pharmacological activities of lipophilic nitroimidazolyl-1, 4-dihydropyridines as calcium channel antagonist
Miri R, et al.
Bioorganic & Medicinal Chemistry, 14(14), 4842-4849 (2006)
Acetoacetylation with 2, 2, 6-trimethyl-4H-1, 3-dioxin-4-one: a convenient alternative to diketene.
Clemens RJ and Hyatt JA.
The Journal of Organic Chemistry, 50(14), 2431-2435 (1985)

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