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Chiral Quest Phosphine Ligands for Asymmetric Hydrogenation

Reactant for:
  • Asymmetric hydrogenation of ketones with TunePhos/diamine/ruthenium complexes
  • Stereoselective preparation of arylalkyl esters via enantioselective hydrogenation of enol acetates

Precatalyst for:
  • Enantioselective iridium-catalyzed carbonyl allylation from alcohol or aldehyde by transfer hydrogenative coupling of allyl acetate

Catalyst for:
  • Enantioselective hydrogenation of a-keto esters to a-hydroxy esters using Ru-tunephos catalysts
Provides comparable or superior enantioselectivities and catalytic abilities to BINAP in Ru-catalyzed asymmetric hydrogenations of β-keto esters, cyclic β-(acylamino)acrylates and a-phthalimide ketones.


100, 500 mg in amber glass bottle

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Synthesis of chiral bisphosphines with tunable bite angles and their applications in asymmetric hydrogenation of beta-ketoesters.
Z Zhang et al.
The Journal of organic chemistry, 65(19), 6223-6226 (2000-09-16)
Wenjun Tang et al.
Journal of the American Chemical Society, 125(32), 9570-9571 (2003-08-09)
Hydrogenation of a series of cyclic beta-(acylamino)acrylates with tetrasubstituted olefins has been accomplished successfully with the use of Ru catalysts with chiral biaryl ligands such as C3-TunaPhos, and up to over 99% ee's have been achieved. This methodology provides an...
Aiwen Lei et al.
Journal of the American Chemical Society, 126(6), 1626-1627 (2004-02-12)
A new type of alpha-phthalimide ketones was hydrogenated in excellent enantioselectivity by using a Ru-(C3-TunePhos) complex as the catalyst. Up to 10 000 turnovers have been achieved in more than 99% ee in the hydrogenation reaction. A dynamic kinetic resolution...

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