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MilliporeSigma

713783

O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol

2,000

Synonym(s):

Polyethylene glycol, α,ω-Bis-NHS-PEG, Di(N-succinimidyl) PEG-diacid, PEG-bis(N-succinimidyl succinate)

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500 MG

$389.00

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About This Item

CAS Number:
186020-53-1
UNSPSC Code:
12162002
NACRES:
NA.22
MDL number:
MFCD03792507

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form

powder

mol wt

average Mn 2,000

reaction suitability

reagent type: cross-linking reagent

Ω-end

NHS ester

α-end

NHS ester

storage temp.

−20°C

Quality Level

100

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1 of 4

This Item
71379115961803537
O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol 2,000

Sigma-Aldrich

713783

O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol

O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol 10,000

Sigma-Aldrich

713791

O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol

O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol 3,000

Sigma-Aldrich

15961

O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol

Bis(NHS)PEG5

Sigma-Aldrich

803537

Bis(NHS)PEG5

form

powder

form

lumps

form

powder

form

liquid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

mol wt

average Mn 2,000

mol wt

average Mn 10,000

mol wt

average Mn 3,000

mol wt

532.5

reaction suitability

reagent type: cross-linking reagent

reaction suitability

reagent type: cross-linking reagent

reaction suitability

reagent type: cross-linking reagent
reactivity: amine reactive

reaction suitability

reagent type: cross-linking reagent

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Ω-end

NHS ester

Ω-end

NHS ester

Ω-end

NHS ester

Ω-end

-

General description

O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol (NHS-PEG-NHS) is a cross-linking reagent.

Application

O,O′-Bis[2-(N-Succinimidyl-succinylamino)ethyl]polyethylene glycol (NHS-PEG-NHS) is suitable reagent used in the covalent conjugation of peanut agglutinin and anticarcinoembryonic antigen antibodies (αCEA) tumor-targeting ligands to near-infrared (NIR)fluorescent superparamagnetic iron oxide (IO)- human serum albumin (HSA) nanoparticles.[1] It is suitable reagent used in the synthesis of novel series of mesoporous silica nanoparticles with different pore sizes, useful for high loading and controlled release of short oligonucleotides.[2]

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH6857
BCCG4340
BCCC7724
BCCC2725
BCCB7092

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Jixi Zhang et al.
Dalton transactions (Cambridge, England : 2003), 43(10), 4115-4126 (2014-01-25)
Aimed at high loading and controlled release of oligonucleotides with short sequences of base-pairs, a novel series of mesoporous silica nanoparticles with three different pore sizes (3.5-5.0 nm) but the same cleavable surface linkers (MSN-Linker-Cys) were synthesized. The small particle
Enav Corem-Salkmon et al.
International journal of nanomedicine, 7, 5517-5527 (2012-11-01)
Colon cancer is one of the major causes of death in the Western world. Early detection significantly improves long-term survival for patients with the disease. Near- infrared (NIR) fluorescent nanoparticles hold great promise as contrast agents for tumor detection. NIR

Articles

Polyethylene Glycol Building Blocks for PEGylation

Circulatory half-life is a key success factor for new drugs. In this respect, PEGylation or PEG-ing—the modification of potential candidates ranging from non-peptidic small molecules to peptides and proteins, antibody fragments, aptamers, and saccharides or oligonucleotides with polyethylene glycol chains—offers numerous advantages.

Injectable Hydrogels for Tissue Regeneration

Hydrogel-based biomaterials for cell delivery and tissue regeneration applications are discussed.

Tailoring Collagen-Based Matrices for Regenerative Medicine and Tissue Engineering

Collagen molecules play a critical role in tissue architecture and strength, and in cell-matrix interactions as insoluble ligands to regulate the diverse phenotypic activities of cells.

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