714151

Fmoc-β-azido-Ala-OH

≥98.0% (HPLC), for peptide synthesis

• Synonym(s): (S)-3-Azido-2-(Fmoc-amino)propionic acid, Fmoc-3-azido-L-alanine
• Empirical Formula (Hill Notation): C₁₈H₁₆N₄O₄
• CAS Number: 684270-46-0
• Molecular Weight: 352.34
• MDL number: MFCD11052919
• UNSPSC Code: 12352209
• PubChem Substance ID: 329763258
• NACRES: NA.26

Properties

• Product Name: Fmoc-β-azido-Ala-OH, ≥98.0% (HPLC)
• Quality Level: 100
• assay: ≥98.0% (HPLC)
• form: lumps
• optical activity: [α]/D -10.0±1.0°, c = 1 in DMF
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis; reaction type: click chemistry
• impurities: 15.3-16.5% nitrogen; 60.1-62.5% carbon
• application(s): peptide synthesis
• functional group: Fmoc
• Storage temp.: 2-8°C
• SMILES string: OC(=O)[C@H](CN=[N+]=[N-])NC(=O)OCC1c2ccccc2-c3ccccc13
• InChI: 1S/C18H16N4O4/c19-22-20-9-16(17(23)24)21-18(25)26-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15/h1-8,15-16H,9-10H2,(H,21,25)(H,23,24)/t16-/m0/s1
• InChI key: ZITYCUDVCWLHPG-INIZCTEOSA-N

Description

Application

Fmoc-β-azido-Ala-OH chloride is a general N-terminal protected reagent used in the solid phase peptide synthesis.[1] Azido group allows it to undergo copper-mediated click chemistry reactions.[2][3]
It can be used in:

• Synthesis of α-N-acetylgalactosamine (α-GalNAc) linked antifreeze glycopeptides (AFGPs).[2]
• Synthesis of stimuli-responsive multifunctional peptide gatekeepers for drug delivery applications.[4]
• Synthesis of triazole-linked glycopeptides via Cu(I)-catalyzed 1,3-dipolar cycloaddition (CuAAC).[3]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves