4,4-Difluoro-L-prolinamide hydrochloride

Name: 4,4-Difluoro-<SC>L</SC>-prolinamide hydrochloride
Brand: ALDRICH
Price: 121 USD
Availability: InStock

97%

Synonym(s):

(S)-4,4-Difluoropyrolidine-2-carboxamide hydrochloride

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500 MG

$121.00

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About This Item

Empirical Formula (Hill Notation):

C₅H₉ClF₂N₂O

CAS Number:

426844-51-1

Molecular Weight:

186.59

NACRES:

NA.22

PubChem Substance ID:

329763452

UNSPSC Code:

12352005

MDL number:

MFCD06797014

Assay:

97%

Form:

solid

Key Documents

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Product Name

4,4-Difluoro-L-prolinamide hydrochloride, 97%

InChI

1S/C5H8F2N2O.ClH/c6-5(7)1-3(4(8)10)9-2-5;/h3,9H,1-2H2,(H2,8,10);1H/t3-;/m0./s1

SMILES string

Cl.NC(=O)[C@@H]1CC(F)(F)CN1

InChI key

RRQDQYAEZGKHOB-DFWYDOINSA-N

assay

97%

form

solid

optical activity

[α]/D −23±5°, c = 0.5 in H₂O

functional group

amide
fluoro

Quality Level

100

Related Categories

Catalysts

Chiral Catalysts & Ligands

Fluorinated Building Blocks

Halogenated Heterocycles

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Show Differences

1 of 4

This Item	679399	151769	S2201
Sigma-Aldrich 717061 4,4-Difluoro-L-prolinamide hydrochloride	Sigma-Aldrich 679399 (S)-(+)-2-Aminobutanamide hydrochloride	Sigma-Aldrich 151769 4-Piperidone monohydrate hydrochloride	Sigma-Aldrich S2201 Semicarbazide hydrochloride
assay 97%	assay 97%	assay 98%	assay ≥99%
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 200
form solid	form solid	form solid	form -
optical activity [α]/D −23±5°, c = 0.5 in H₂O	optical activity [α]22/D +24°, c = 1 in H₂O	optical activity -	optical activity -
functional group amide	functional group amide, amine	functional group hydroxyl	functional group -

Application

4,4-Difluoro-L-prolinamide hydrochloride can be used as a building block in the synthesis of cyanopyrrolidine based DPP-IV inhibitors.[1]

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

MKBC0703

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Synthesis and structure-activity relationships of potent 3-or 4-substituted-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors

Fukushima H, et al.

Bioorganic & Medicinal Chemistry, 12(23), 6053-6061 (2004)

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