718742

BrettPhos

98%

• Synonym(s): 2-(Dicyclohexylphosphino)3,6-dimethoxy-2′,4′,6′-triisopropyl-1,1′-biphenyl
• Empirical Formula (Hill Notation): C₃₅H₅₃O₂P
• CAS Number: 1070663-78-3
• Molecular Weight: 536.77
• MDL number: MFCD11973797
• PubChem Substance ID: 329763602
• NACRES: NA.22

Properties

• Quality Level: 300
• Assay: 98%
• form: solid
• reaction suitability: reaction type: Cross Couplings; reagent type: ligand; reaction type: Buchwald-Hartwig Cross Coupling Reaction; reagent type: ligand; reaction type: Fluorinations
• greener alternative product score: old score: 8; new score: 1; Find out more about DOZN™ Scoring
• greener alternative product characteristics: Waste Prevention; Atom Economy; Design for Energy Efficiency; Learn more about the Principles of Green Chemistry.
• mp: 187-195 °C
• functional group: phosphine
• greener alternative category: Re-engineered
• SMILES string: COc1c(P(C2CCCCC2)C3CCCCC3)c(c4c(C(C)C)cc(C(C)C)cc4C(C)C)c(OC)cc1
• InChI: 1S/C35H53O2P/c1-23(2)26-21-29(24(3)4)33(30(22-26)25(5)6)34-31(36-7)19-20-32(37-8)35(34)38(27-15-11-9-12-16-27)28-17-13-10-14-18-28/h19-25,27-28H,9-18H2,1-8H3
• InChI key: WDVGNXKCFBOKDF-UHFFFAOYSA-N

Description

General description

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Atom Economy” and “Design for Energy Efficiency”. Click here to view its DOZN scorecard.

Application

Buchwald Phosphine Ligands for chemical Synthesis

BrettPhos is a dialkylbiaryl phosphine ligand developed by the Buchwald group. It promotes cross-coupling reactions more efficiently and exhibits improved reactivity compared to other catalytic systems.
It can be used in:

• palladium-catalyzed trifluoromethylation of aryl chlorides
• Buchwald-Hartwig amination
• synthesis of 4-aryl and alkyl substituted, N⁶-alkylated pyridazine-3,6-diamines via a Buchwald protocol

Features and Benefits

• White crystalline solid
• Air- and moisture-stable
• Thermally stable
• Highly efficient
• Wide functional group tolerance
• Excellent selectivity and conversion

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable