721174

2-(Tributylstannyl)pyrimidine

95%

• Synonym(s): 2-Tributylstannanylpyrimidine, Tributyl (2-pyrimidyl)stannane
• Empirical Formula (Hill Notation): C₁₆H₃₀N₂Sn
• CAS Number: 153435-63-3
• Molecular Weight: 369.13
• MDL number: MFCD01319085
• UNSPSC Code: 12352103
• PubChem Substance ID: 329763826
• NACRES: NA.22

Properties

• assay: 95%
• form: liquid
• refractive index: n20/D 1.512
• density: 1.164 g/mL at 25 °C
• SMILES string: CCCC[Sn](CCCC)(CCCC)c1ncccn1
• InChI: 1S/C4H3N2.3C4H9.Sn/c1-2-5-4-6-3-1;3*1-3-4-2;/h1-3H;3*1,3-4H2,2H3;
• InChI key: WTFFOOAJSDVASL-UHFFFAOYSA-N

Description

Application

2-(Tributylstannyl)pyrimidine is an organotin compound used in Stille coupling reaction.[1] This can be used as one of the precursors in the synthesis of 2-aminopyridine oxazolidinones as potent and selective tankyrase (TNKS) inhibitors[2] and the synthesis of canagliflozin, a novel inhibitor for sodium-dependent glucose cotransporter.[3]
It can also be used in the preparation of various (2-pyrimidyl)silanes.[4]

Safety Information

• pictograms: GHS06,GHS08,GHS09
• signalword: Danger
• hcodes: H301,H312,H315,H319,H360FD,H372,H410
• pcodes: P202 - P273 - P280 - P301 + P310 - P302 + P352 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT RE 1
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable