Product 724858, poly(N-isopropylacrylamide-co-methacrylic acid), is a random copolymer and is synthesized by a conventional radical polymerization route.
724858
Poly(N-isopropylacrylamide-co-methacrylic acid)
methacrylic acid 10 mol %, Mn 60,000
Synonym(s):
Poly(NIPAM-co-MAA), Polyacrylamide, functionalized polyNIPAM, functionalized polyacrylamide, polyNIPAM
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5 G
$537.00
About This Item
Linear Formula:
(C6H11NO)m (C4H6O2)n
CAS Number:
MDL number:
UNSPSC Code:
12162002
NACRES:
NA.23
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form
solid
Quality Level
mol wt
Mn 60,000
composition
methacrylic acid, 10 mol %
mp
>300 °C
Mw/Mn
≤2.5
SMILES string
N(C(C)C)C(=O)C=C.OC(=O)C(=C)C
InChI
1S/C6H11NO.C4H6O2/c1-4-6(8)7-5(2)3;1-3(2)4(5)6/h4-5H,1H2,2-3H3,(H,7,8);1H2,2H3,(H,5,6)
Inchi Key
BGJOTKHBFYMJST-UHFFFAOYSA-N
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Related Categories
1 of 4
This Item | 724823 | 724831 | 724807 |
|---|---|---|---|
| form solid | form solid | form solid | form powder |
| mp >300 °C | mp - | mp - | mp >300 °C |
| mol wt Mn 60,000 | mol wt Mn 2000-3000 (by HCL Titration) | mol wt average Mn 5,500 (HCl titration) | mol wt average Mn 5,000 |
| composition methacrylic acid, 10 mol % | composition - | composition - | composition - |
| Mw/Mn ≤2.5 | Mw/Mn - | Mw/Mn - | Mw/Mn - |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
Application
Intelligent Swelling/Collapsing copolymer that can be used as a temperature- and pH-sensitive materials.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Pierre Simard et al.
International journal of pharmaceutics, 381(2), 86-96 (2009-05-19)
A promising avenue in cancer therapy using liposomal formulations is the combination of site-specific delivery with triggered drug release. The use of trigger mechanisms in liposomes could be relevant for drugs susceptible to lysosomal hydrolytic/enzymatic degradation. Here, we propose a
Sabrina Schmidt et al.
Langmuir : the ACS journal of surfaces and colloids, 27(16), 9801-9806 (2011-07-09)
Charged poly(N-isopropylacrylamide-co-methacrylic acid) [P(NiPAM-co-MAA)] microgels can stabilize thermo- and pH-sensitive emulsions. By placing charged units at different locations in the microgels and comparing the emulsion properties, we demonstrate that their behaviors as emulsion stabilizers are very different from molecular surfactants
Eunice Costa et al.
Langmuir : the ACS journal of surfaces and colloids, 28(26), 10082-10090 (2012-06-09)
The layer-by-layer (LbL) assembly of polyelectrolyte pairs on temperature and pH-sensitive cross-linked poly(N-isopropylacrylamide)-co-(methacrylic acid), poly(NIPAAm-co-MAA), microgels enabled a fine-tuning of the gel swelling and responsive behavior according to the mobility of the assembled polyelectrolyte (PE) pair and the composition of
J Moselhy et al.
Journal of biomaterials science. Polymer edition, 11(2), 123-147 (2000-03-16)
The pH- and temperature-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAm/MAA) nanoparticles are of potential application in targeted drug delivery. Their responsive properties in the presence of human serum albumin were investigated using dynamic light scattering (DLS), protein assay, and electron spin resonance (ESR)
Samer R Abulateefeh et al.
Macromolecular bioscience, 11(12), 1722-1734 (2011-10-21)
Many difficulties in treating cancer arise from the problems in directing highly cytotoxic agents to the deseased tissues, cells and intracellular compartments. Many drug delivery systems have been devised to address this problem, including those that show a change in
Articles
Microparticles in drug delivery: Study on controlling chitosan microparticle size and distribution, exploring encapsulation of BSA and TPP cross-linker.
Poly(N-isopropylacrylamide), or PNIPAM, is a stimuli-responsive polymer that responds to changes in pH and temperature and has a LCST around 32 C.
Professor Mitsuhiro Ebara provides insights on several types of smart nanofiber mesh systems that have been explored for different drug delivery purposes.
By altering the physicochemical properties, smart or intelligent drug delivery systems can be designed to deliver therapeutic molecules on-demand. Learn more about the application of stimuli-responsive materials in drug delivery.
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