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730998

Sigma-Aldrich

tBuBrettPhos

97%

Synonym(s):
t-Bu Brett Phos, t-BuBrett-Phos, tertButylBrettPhos, 2-(Di-tert-butylphosphino)-2′,4′,6′- triisopropyl-3,6-dimethoxy-1,1′-biphenyl, t-BuBrett Phos, t-BuBrettPhos, [3,6-Dimethoxy-2′,4′,6′-tris(1-methylethyl) [1,1′-biphenyl]-2-yl]bis(1,1-dimethylethyl)phosphine, tert-ButylBrettPhos
Empirical Formula (Hill Notation):
C31H49O2P
CAS Number:
Molecular Weight:
484.69
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

97%

form

solid

reaction suitability

reaction type: Cross Couplings
reagent type: ligand
reaction type: Arylations

reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction

reagent type: ligand
reaction type: C-X Bond Formation

reagent type: ligand
reaction type: Fluorinations

mp

166-170 °C

functional group

phosphine

SMILES string

COc1ccc(OC)c(c1P(C(C)(C)C)C(C)(C)C)-c2c(cc(cc2C(C)C)C(C)C)C(C)C

InChI

1S/C31H49O2P/c1-19(2)22-17-23(20(3)4)27(24(18-22)21(5)6)28-25(32-13)15-16-26(33-14)29(28)34(30(7,8)9)31(10,11)12/h15-21H,1-14H3

InChI key

REWLCYPYZCHYSS-UHFFFAOYSA-N

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tBuBrettPhos 97%

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695211

tBuMePhos

TBADN AldrichCPR

Sigma-Aldrich

L512109

TBADN

PBTTPD

Sigma-Aldrich

745901

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assay

97%

assay

-

assay

-

assay

-

form

solid

form

solid

form

-

form

solid

reaction suitability

reaction type: Cross Couplings, reagent type: ligand
reaction type: Arylations, reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction, reagent type: ligand
reaction type: C-X Bond Formation, reagent type: ligand
reaction type: Fluorinations

reaction suitability

-

reaction suitability

-

reaction suitability

-

mp

166-170 °C

mp

90-95 °C

mp

-

mp

-

functional group

phosphine

functional group

phosphine

functional group

-

functional group

-

Quality Level

300

Quality Level

100

Quality Level

-

Quality Level

100

General description

tBuBrettPhos is a dialkylbiaryl phosphine ligand developed by the Buchwald group. It promotes cross-coupling reactions more efficiently and exhibits improved reactivity compared to other catalytic systems.

Application

Common applications
  • Buchwald-Hartwig amination and C-O coupling
  • Suzuki, Negishi, Stille, Hiyama, Sonogashira cross-couplings
  • α-Arylation reaction


New Applications:
  • Conversion of aryl and vinyl triflates to bromides and chlorides
  • Conversion of aryl triflates to aryl fluorides
  • O-Arylation of ethyl acetohydroximate
  • Conversion of aryl chlorides and sulfonates to nitroaromatics

Features and Benefits

  • White crystalline solid
  • Air- and moisture-stable
  • Thermally stable
  • Highly efficient
  • Wide functional group tolerance
  • Excellent selectivity and conversion

Legal Information

Usage subject to US Patent 7,858,784

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

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