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739960

Resomer® RG 505, Poly(D,L-lactide-co-glycolide)

ester terminated, Mw 54,000-69,000

Synonym(s):

PLGA

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1 g
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$100.00
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$320.00

About This Item

Linear Formula:
[C3H4O2]x[C2H2O2]y
CAS Number:
26780-50-7
MDL number:
MFCD00131930
UNSPSC Code:
12162002
NACRES:
NA.23

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Quality Level

100

form

amorphous

feed ratio

lactide:glycolide 50:50

mol wt

Mw 54,000-69,000

degradation timeframe

<3 months

viscosity

0.61-0.74 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

transition temp

Tg 48-52 °C

storage temp.

2-8°C

SMILES string

O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key

LCSKNASZPVZHEG-UHFFFAOYSA-N

General description

Poly(lactide-co-glycolide)(PLGA) is a biodegradable polymer used in the preparation of polymericmicrospheres. These polymers degrade in vivo by hydrolysis of their esterbackbone into non-toxic products, which are excreted by the kidneys oreliminated as CO2 and water through biochemical pathways. PLGAmicrospheres have been widely used to encapsulate drug molecules and have beenused as long-acting, sustained-release pharmaceutical formulations.

Application

Poly(lactide-co-glycolide)(PLGA) can be used to fabricate sustained-release drug delivery systems, for example, it can be used to encapsulate the anti-inflammatory lipophilic drug atorvastatin.

Legal Information

Product of Evonik
RESOMER is a registered trademark of Evonik Rohm GmbH

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This Item
719919769797739944
Resomer&#174; RG 505, Poly(D,L-lactide-co-glycolide) ester terminated, Mw 54,000-69,000

Sigma-Aldrich

739960

Resomer® RG 505, Poly(D,L-lactide-co-glycolide)

Resomer&#174; RG 752 H, Poly(D,L-lactide-co-glycolide) acid terminated, lactide:glycolide 75:25, Mw 4,000-15,000

Sigma-Aldrich

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Resomer® RG 752 H, Poly(D,L-lactide-co-glycolide)

Resomer&#174; RG 755 S, Poly(D,L-lactide-co-glycolide) ester terminated

Sigma-Aldrich

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Resomer® RG 755 S, Poly(D,L-lactide-co-glycolide)

Resomer&#174; RG 504, Poly(D,L-lactide-co-glycolide) lactide:glycolide 50:50, ester terminated, Mw 38,000-54,000

Sigma-Aldrich

739944

Resomer® RG 504, Poly(D,L-lactide-co-glycolide)

viscosity

0.61-0.74 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

viscosity

0.14-0.22 dL/g, 0.5 % in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

viscosity

0.50-0.70 dL/g

viscosity

0.45-0.60 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

form

amorphous

form

(Powder or Solid or Chunk(s))

form

amorphous

form

amorphous

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

degradation timeframe

<3 months

degradation timeframe

<6 months

degradation timeframe

-

degradation timeframe

<3 months

transition temp

Tg 48-52 °C

transition temp

Tg 42-46 °C

transition temp

Tg 48-54 °C

transition temp

Tg 46-50 °C

mol wt

Mw 54,000-69,000

mol wt

Mw 4,000-15,000

mol wt

-

mol wt

Mw 38,000-54,000

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB8251
SDBB3928
SDBB0464
STBL2290
STBK8649

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Global Trade Item Number

SKUGTIN
739960-5G04061832884196
739960-1G04061832884189

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. what is the method of preparation/ synthesis of poly ( D, L- Lactide-co-glycolide) from vegetable oil

    1 answer

    1. This product is an M-Clarity level 100 item. The method of preparation is considered proprietary.

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