Resomer^® RG 858 S, Poly(D,L-lactide-co-glycolide)

Name: Resomer<SUP>®</SUP> RG 858 S, Poly(<SC>D,L</SC>-lactide-<I>co</I>-glycolide)
Brand: ALDRICH

ester terminated, lactide:glycolide 85:15, M_w 190,000-240,000

Synonym(s):

PLGA

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About This Item

Linear Formula:

[C₃H₄O₂]_x[C₂H₂O₂]_y

CAS Number:

26780-50-7

MDL number:

MFCD00131930

UNSPSC Code:

12162002

NACRES:

NA.23

Key Documents

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Product Name

Resomer^® RG 858 S, Poly(D,L-lactide-co-glycolide), ester terminated, lactide:glycolide 85:15, M_w 190,000-240,000

SMILES string

O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key

LCSKNASZPVZHEG-UHFFFAOYSA-N

form

amorphous

feed ratio

lactide:glycolide 85:15

mol wt

M_w 190,000-240,000

degradation timeframe

<9 months

viscosity

1.3-1.7 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

storage temp.

2-8°C

Quality Level

100

Related Categories

Biomedical Materials

Biomedical Polymers

Materials Science

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This Item	719919	769789	739960
Sigma-Aldrich 739979 Resomer^® RG 858 S, Poly(D,L-lactide-co-glycolide)	Sigma-Aldrich 719919 Resomer^® RG 752 H, Poly(D,L-lactide-co-glycolide)	Sigma-Aldrich 769789 Resomer^® RG 757 S, Poly(D,L-lactide-co-glycolide)	Sigma-Aldrich 739960 Resomer^® RG 505, Poly(D,L-lactide-co-glycolide)
viscosity 1.3-1.7 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)	viscosity 0.14-0.22 dL/g, 0.5 % in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)	viscosity 0.9-1.3 dL/g	viscosity 0.61-0.74 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)
form amorphous	form (Powder or Solid or Chunk(s))	form amorphous	form amorphous
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
feed ratio lactide:glycolide 85:15	feed ratio lactide:glycolide 75:25	feed ratio lactide:glycolide 75:25	feed ratio lactide:glycolide 50:50
mol wt M_w 190,000-240,000	mol wt M_w 4,000-15,000	mol wt -	mol wt M_w 54,000-69,000
degradation timeframe <9 months	degradation timeframe <6 months	degradation timeframe -	degradation timeframe <3 months

Application

Controlled release

Electrospun Resomer^® X 206 S blended with cellulose from bagasse can be used as a scaffold in tissue engineering.

Features and Benefits

Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.

General description

RESOMER^® polymers are bioresorbable aliphatic polyesters comprised of a range of different ratios of lactide and glycolide monomers, PLA stereochemistries, and end-group functionalization. These biodegradeable homopolymers and copolymers of lactide and glycolide afford a variety of properties that range from very stiff, hard semi-crystalline materials with long degradation times, to softer, amorphous materials with faster degradation rates.[1]

Legal Information

Product of Evonik

RESOMER is a registered trademark of Evonik Rohm GmbH

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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RESOMER??Biodegradeable Polymers for Sutures, Medical Devices, Drug Delivery Systems and Tissue Engineering

Mader K

Material Matters, 6(3), 62-62 (2011)

Effect of water on exenatide acylation in poly(lactide-co-glycolide) microspheres.

Rongcai Liang et al.

International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)

Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative

Acetalated dextran is a chemically and biologically tunable material for particulate immunotherapy.

Kyle E Broaders et al.

Proceedings of the National Academy of Sciences of the United States of America, 106(14), 5497-5502 (2009-03-27)

Materials that combine facile synthesis, simple tuning of degradation rate, processability, and biocompatibility are in high demand for use in biomedical applications. We report on acetalated dextran, a biocompatible material that can be formed into microparticles with degradation rates that

A single-surgeon randomized trial comparing three meshes in lichtenstein hernia repair: 2- and 5-year outcome of recurrences and chronic pain.

Hannu Paajanen et al.

International journal of surgery (London, England), 11(1), 81-84 (2012-12-19)

Chronic pain may be a major long-term problem related to mesh material and operative trauma in inguinal hernioplasty. Lichtenstein hernioplasty was performed under local anaesthesia in 312 patients by the same surgeon and technique between 2003 and 2005. The patients

Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis.

Daniel R Getts et al.

Nature biotechnology, 30(12), 1217-1224 (2012-11-20)

Aberrant T-cell activation underlies many autoimmune disorders, yet most attempts to induce T-cell tolerance have failed. Building on previous strategies for tolerance induction that exploited natural mechanisms for clearing apoptotic debris, we show that antigen-decorated microparticles (500-nm diameter) induce long-term

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Resomer® RG 858 S, Poly(D,L-lactide-co-glycolide)

ester terminated, lactide:glycolide 85:15, Mw 190,000-240,000