740543

Sigma-Aldrich

1α,25-Dihydroxyvitamin D3 (6,19,19-d3) solution

50 μg/mL in ethanol, 97 atom % D, 96% (CP)

Synonym(s):
Deuterated 1-α25-Dihydroxyvitamin D3 solution, 1α,25-Dihydroxycholecalciferol (6,19,19-d3) solution, Calcitriol (6,19,19-d3) solution
Empirical Formula (Hill Notation):
C27D3H41O3
CAS Number:
Molecular Weight:
419.65
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

isotopic purity

97 atom % D

assay

96% (CP)

form

solution

concentration

50 μg/mL in ethanol

application(s)

detection: suitable
mass spectrometry (MS): suitable

color

colorless

mp

-144.0 °C

mass shift

M+3

storage temp.

−20°C

SMILES string

[2H]/C([2H])=C1[C@@H](O)C[C@H](O)CC\1=C([2H])\C=C2/CCC[C@]3(C)[C@H](CC[C@@H]23)[C@H](C)CCCC(C)(C)O

InChI

1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1/i2D2,11D

InChI key

GMRQFYUYWCNGIN-POLIPXRRSA-N

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General description

1α,25-Dihydroxyvitamin D3 [1,25(OH)2D3], also known as calcitriol, plays a role in calcium and phosphate metabolism in humans. It also regulates insulin secretion and induces cellular differentiation.
1α,25-Dihydroxyvitamin D3 (6,19,19-d3) is a deuterated vitamin D3 wherein C-6 and C-19 protons are replaced by deuterium.

Application

1α,25-Dihydroxyvitamin D(6,19,19-d3) can be used as a stable isotope internal standard for accurate data interpretation in specific biological samples by mass spectrometry.

Packaging

1 mL in ampule

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Precautionary Statements

RIDADR

UN1170 - class 3 - PG 2 - Ethanol, solution

WGK Germany

WGK 1

Flash Point(F)

57.2 °F - closed cup

Flash Point(C)

14.0 °C - closed cup

Certificate of Analysis

Certificate of Origin

Jianqiong Zheng et al.
Frontiers in pharmacology, 11, 97-97 (2020-03-19)
Metabolic syndrome is a disorder of energy use and storage, which is characterized by central obesity, dyslipidemia, and raised blood pressure and blood sugar levels. Maternal 25-hydroxyvitamin D deficiency is known to cause metabolic changes, chronic disease, and increased adiposity...
Vitamin D3: a helpful immuno-modulator
Di R, et al.
Immunology, 134(2), 123-139 (2011)
The emerging role of vitamin D3 in women′s health
Khadilkar, SS
The Journal of Obstetrics and Gynecology of India, 63(2), 147?150-147?150 (2013)
Xinzhu Liu et al.
Burns & trauma, 8, tkaa042-tkaa042 (2021-01-28)
Gut ischemia and hypoxia post severe burn leads to breakdown of intestinal epithelial barrier and enteric bacterial translocation (EBT), resulting in serious complications, such as systemic inflammatory response syndrome, sepsis and multiple organ failure. Cystic fibrosis transmembrane conductance regulator (CFTR)...

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