745499

Sigma-Aldrich

Zinc trifluoroethanesulfinate

Synonym(s):
Bis(((2,2,2-trifluoroethyl)sulfinyl)oxy)zinc, TFES, Baran TFES Reagent, Baran Trifluoroethylation Reagent
Empirical Formula (Hill Notation):
C4H4F6O4S2Zn
CAS Number:
Molecular Weight:
359.58
MDL number:
PubChem Substance ID:
NACRES:
NA.22

reaction suitability

reagent type: catalyst
reaction type: C-H Activation

Quality Level

mp

114-120 °C

SMILES string

O=S(O[Zn]OS(CC(F)(F)F)=O)CC(F)(F)F

InChI

1S/2C2H3F3O2S.Zn/c2*3-2(4,5)1-8(6)7;/h2*1H2,(H,6,7);/q;;+2/p-2

InChI key

PUGHSSOALZPRJD-UHFFFAOYSA-L

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General description

Zinc trifluoroethanesulfinate (TFES) is part of a zinc sulfinate toolbox developed by Phil Baran for the simple and rapid diversification of heterocycles.

Practical and Innate Carbon-Hydrogen Functionalization of Heterocycles

Learn More at the
Professor and Product Portal of Professor Phil S. Baran.

Packaging

1, 10 g in glass bottle

Linkage

Frequently Asked Questions are available for this Product.

Other Notes

Previously sold under product number L511234

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Fionn O'Hara et al.
Journal of the American Chemical Society, 135(32), 12122-12134 (2013-07-19)
Radical addition processes can be ideally suited for the direct functionalization of heteroaromatic bases, yet these processes are only sparsely used due to the perception of poor or unreliable control of regiochemistry. A systematic investigation of factors affecting the regiochemistry...
Yuta Fujiwara et al.
Nature, 492(7427), 95-99 (2012-12-04)
Nitrogen-rich heterocyclic compounds have had a profound effect on human health because these chemical motifs are found in a large number of drugs used to combat a broad range of diseases and pathophysiological conditions. Advances in transition-metal-mediated cross-coupling have simplified...
Articles
The synthesis of heteroaromatic and aromatic compounds is at the heart of the chemical industry. The ever-growing demand for new chemical entities, coupled with dwindling resources and time constraints allotted to any given research project, a rapid way to diversify (hetero)aromatic scaffolds is needed.
Read More

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