These 5 nm gold nanoparticles are indeed suitable for developing peptide and protein gold conjugates, and they are commonly used in applications such as blotting, lateral flow assays, microscopy, and transmission electron microscopy (TEM). However, they have not been specifically tested for CryoElectron tomography.
Regarding affinity with proteins, including Amyloid beta peptides, while gold nanoparticles can interact with various biomolecules, the specific affinity would depend on the surface chemistry and functionalization of the nanoparticles.
752568
Gold nanoparticles
5 nm diameter, OD 1, suspension in 0.1 mM PBS, reactant free
Synonym(s):
Au NP, Gold colloid
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| Size/SKU | Availability | Price |
|---|---|---|
25 mL | Available to ship TODAYfromMILWAUKEE | $174.00 $130.50 |
100 mL | Available to ship TODAYfromMILWAUKEE | $557.00 $417.75 |
About This Item
$130.50
List Price$174.00Save 25%Web-Only Promotion
Available to ship TODAYDetails
Quality Segment
form
nanoparticles, suspension
concentration
~5.5E+13 particles/mL
OD
1
diameter
5 nm
λmax
510-520 nm
storage temp.
2-8°C
SMILES string
[Au]
InChI
1S/Au
InChI key
PCHJSUWPFVWCPO-UHFFFAOYSA-N
General description
Goldnanoparticles with size of 5 nm and polydispersity index of <0.2 offer unique characteristics and have diverse applications in various industries. PBS maintains a physiological pH and prevents aggregation of nanoparticles. Smaller nanoparticles exhibit unique optical properties, including a strong surface plasmon resonance (SPR), which can be utilized in imaging and sensing applications. Small size also allows for enhanced permeability and retention effect in tumors, making them effective carriers for targeted drug delivery.
Application
- Gold nanoparticles: Synthesis properties and applications: A comprehensive overview of the methods for synthesizing gold nanoparticles and their broad range of applications (I Hammami, NM Alabdallah, 2021).
Legal Information
Product of CytoDiagnostics, Inc.
1 of 1
This Item | |||
|---|---|---|---|
| form nanoparticles, suspension | form nanoparticles, suspension | form nanoparticles, suspension | form nanoparticles, suspension |
| OD 1 | OD 1 | OD 1 | OD - |
| diameter 5 nm | diameter 10 nm | diameter 60 nm | diameter 400 nm |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| concentration ~5.5E+13 particles/mL | concentration ~6.0E+12 particles/mL | concentration ~1.9E+10 particles/mL | concentration ~1.9E+8 particles/mL |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 100 |
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Are these 5nm gold nanoparticles suitable for CryoElectron tomography sample preparation. Can you please tell if they have any sort of affinity with the protein particularly Amyloid beta peptides.
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What is the composition and pH of 0.1mM PBS?
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The pH of this product is not determined. Based on the product page, the only listed components are Gold nanoparticles in 0.1 mM phosphate-buffered saline (PBS). Any other components are considered proprietary.
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Could you please confirm whether the nanoparticles are sterile and are suitable for cell-based experiments? If not sterile, what recommended sterilization method should I use to ensure their sterility?
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This product is not sterile. Please see the links below to publications that offer information on sterilization of gold nanoparticles:
https://pubs.acs.org/doi/10.1021/acs.langmuir.2c01557#:~:text=3.3.-,1.,C%20for%20about%2020%20min.
https://pubs.acs.org/doi/10.1021/acs.langmuir.2c01557
https://pubmed.ncbi.nlm.nih.gov/19937607/Helpful?
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What is the Z potential of the nanoparticles?
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The product in question has a net negative charge with a zeta potential in the range of –20mV to –30mV.
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How do you attach gold nanoparticles to peptides and peptide conjugates?
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To view information on how to attach gold nanoparticles to peptides and peptide conjugates, please view the information in the reference - Rosenthal, S. J. and Wright, D. W. (Eds.). (2005), p. 91-92. NanoBiotechnology Protocols. New Jersey. Humana Press.
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What is the shape of the gold nanoparticles?
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The majority (>95%) of the gold nanoparticles are spherical.
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My gold nanoparticles settle out of solution upon storage. Is this normal?
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Settling of gold nanoparticles on the bottom of the storage flask is completely normal and is especially common for larger sized particles, which settles at greater speed. Settling does not affect the performance of the particles. Prior to use, simply swirl the solution to properly disperse your gold nanoparticles and obtain a homogenous solution.
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Why does my gold nanoparticle solution turn violet when I add salt containing buffer?
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Due to repulsive forces arising from the surface charge of gold nanoparticles, an energy barrier must be overcome for individual particles to interact. When no (or small) amounts of electrolytes such as NaCl is present, this energy barrier is too strong for interaction to occur between particles. However, upon addition of NaCl this energy barrier is reduced allowing the gold nanoparticles to interact and aggregate. This aggregation causes a phenomenon called surface-plasmon coupling which changes the adsorption maximum of light to a higher wavelength resulting in a change in color of the solution.
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Which gold nanoparticle size should I choose for my application?
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The size of gold nanoparticle to use is very depandent upon the intended application. Generally, smaller particles offer better sensitivity in applications such as immunogold labeling due to less steric hindrance and the ability to bind more gold nanoparticles to the desired target. Small gold nanoparticles are less visible than larger particles, however, which must also be taken into account.As an application example, particles with a size between 30-50nm are particularly useful for the development of rapid tests such as lateral flow assays.
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How do you attach gold nanoparticles to oligos?
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To attach gold nanoparticles to oligos please view the information in the attached reference - Bioconjug Chem. 2011 Apr 20;22(4):794-807. Epub 2011 Mar 28.
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