Jones reagent

Chromium trioxide solution in sulfuric acid, Jone′s reagent, Sulfuric acid-chromium trioxide mixture
CAS Number:
MDL number:
PubChem Substance ID:

Quality Level


2 M CrO3 in aqueous H2SO4

reaction suitability

core: chromium
reagent type: catalyst
reagent type: oxidant


1.298 g/mL at 25 °C

SMILES string




InChI key


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General description

  • Jones reagent is a solution of chromium trioxide in aqueous sulfuric acid.
  • Using acetone as a reaction solvent, the reagent is usually used for the oxidation of primary and secondary alcohols to carboxylic acids and ketones, respectively.
  • The oxidation is very rapid and exothermic.
  • The reagent tolerates a variety of functionalities, such as, for example, unsaturated bonds, which are rarely oxidized.

For a comprehensive review of chromium-based reagents, see "Oxidation of Alcohols to Aldehydes and Ketones" by Tojo and Fernández, Springer Berlin, 2006, 1-97.


Jones reagent can be used:
  • In the oxidative cleavage of various alkenes into carboxylic acids and ketones using a catalytic amount of osmium tetroxide.
  • To prepare symmetrical binaphthols by oxidative dehydrodimerization of substituted naphthols.
  • To synthesize acyl-naphthols and substituted isocoumarins from 2-(4-hydroxy-but-1-ynyl)benzaldehydes.


25, 100 mL in glass bottle

Signal Word


Target Organs

Respiratory system


UN 3098 5.1(8) / PGII

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Tunable Synthesis of 3-Acyl-2-naphthols and 3-Substituted Isocoumarins via Jones Reagent Promoted Cascade Reactions of 2-(4-Hydroxy-but-1-ynyl) benzaldehydes
He Y, et al.
The Journal of Organic Chemistry, 78(20), 10178-10191 (2013)
Jones, E. R. H.
Journal of the Chemical Society, 2548-2548 (1953)
Oxidative coupling of 2-substituted 1, 2-dihydro-1-naphthols using Jones reagent: a simple entry into 3, 3?-disubstituted 1, 1?-binaphthyl-4, 4?-diols
Fillion E, et al.
Tetrahedron Letters, 46(7), 1091-1094 (2005)
A convenient, mild method for oxidative cleavage of alkenes with Jones reagent/osmium tetraoxide
Henry JR and Weinreb SM
The Journal of Organic Chemistry, 58(17), 4745-4745 (1993)
Heilbron, I. M.; et al.
Journal of the Chemical Society, 604-604 (1949)

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