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Sigma-Aldrich

PEGA resin

extent of labeling: ~0.4 mmol/g loading

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Synonym(s):
Poly[acryloyl-bis(aminopropyl)polyethylene glycol]
MDL number:
NACRES:
NA.22

product line

PEGA

Quality Level

form

crystals

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

extent of labeling

~0.4 mmol/g loading

impurities

90% methanol

particle size

150-300 μm

functional group

amine

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General description

PEGA resins are a hydrophilic acrylamide-PEG co-polymer providing a really extensive and more uniform swelling in a wide range of solvents (from water, methanol, ethanol to tetrahydrofuran, acetonitrile and toluene). The extreme swelling volume of this support in the standard peptide synthesis solvents DCM and DMF together with their good stability make them ideally suited for the batch as well as for continuous-flow syntheses.

Application

Polyacrylamide resin possessing long polyethylene glycol spacers giving extremely high swell resin may be used for:
  • immobilizing enzymes in aqueous solution
  • affinity purification of small-molecule binding proteins
  • synthesis of peptide libraries with fluorescently labeled proteins

Packaging

Sold on basis of weight of dry resin.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Product Number
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25G
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705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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Customers Also Viewed

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Catch and release of concanavalin A by a mannose-immobilized photoaffinity PEGA resin coupled with a cleavable disulfide linker.
Kuramochi K, et al.
Bioscience, Biotechnology, and Biochemistry, 79(12), 1946-1953 (2015)
Chemical ligation of unprotected peptides directly from a solid support.
Camarero JA, et al.
The Journal of Peptide Research, 51(4), 303-316 (1998)
Pega: a flow stable polyethylene glycol dimethyl acrylamide copolymer for solid phase synthesis.
Meldal M, et al.
Tetrahedron Letters, 33(21), 3077-3080 (1992)
Specificity Profiling of Protein?Binding Domains Using One?Bead?One?Compound Peptide Libraries.
Kunys AR, et al.
Current Protocols in Chemical Biology, 331-355 (2012)
Identification of small molecule binding molecules by affinity purification using a specific ligand immobilized on PEGA resin.
Kuramochi K, et al.
Bioconjugate Chemistry, 19(12), 2417-2426 (2008)

Related Content

The high swelling volume of PEGA resins makes the functionalities located within the polymer bead accessible to large biomolecules.

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