Nicotinamide-2,4,5,6-d₄

Name: Nicotinamide-2,4,5,6-d<SUB>4</SUB>
Brand: ALDRICH

98 atom % D, 98% (CP)

Synonym(s):

Vitamin B3-2,4,5,6-d₄

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Note: This product can be packaged on demand. For information on pricing, availability and packaging of custom sizes, please contact Stable Isotopes Customer Service

About This Item

Empirical Formula (Hill Notation):

C₆D₄H₂N₂O

CAS Number:

347841-88-7

Molecular Weight:

126.15

UNSPSC Code:

12352005

PubChem Substance ID:

329767015

MDL number:

MFCD01074140

Isotopic purity:

98 atom % D

Assay:

98% (CP)

Mass shift:

M+4

Form:

powder

Key Documents

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InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)/i1D,2D,3D,4D

SMILES string

NC(C1=C([2H])N=C([2H])C([2H])=C1[2H])=O

InChI key

DFPAKSUCGFBDDF-RHQRLBAQSA-N

isotopic purity

98 atom % D

assay

98% (CP)

form

powder

technique(s)

mass spectrometry (MS): suitable

color

white

mp

133 °C

mass shift

M+4

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This Item	809799	592021	486086
Sigma-Aldrich 762970 Nicotinamide-2,4,5,6-d₄	Sigma-Aldrich 809799 Nicotinamide-2,6,7-¹³C₃-(pyridyl-¹⁵N)	Sigma-Aldrich 592021 Nicotinamide-(amide-¹⁵N)	Sigma-Aldrich 486086 Nicotinic acid-(ring-d₄)
assay 98% (CP)	assay ≥98% (CP)	assay 98% (CP)	assay ≥98% (CP)
isotopic purity 98 atom % D	isotopic purity ¹³C, ¹⁵N, ≥98 atom %	isotopic purity 98 atom % ¹⁵N	isotopic purity ≥98 atom % D
technique(s) mass spectrometry (MS): suitable	technique(s) mass spectrometry (MS): suitable	technique(s) mass spectrometry (MS): suitable	technique(s) mass spectrometry (MS): suitable, protein expression: suitable
mass shift M+4	mass shift M+4	mass shift M+1	mass shift M+4
form powder	form powder	form solid	form powder
mp 133 °C	mp 128 °C	mp 130-132 °C (lit.)	mp 236-239 °C (lit.)

General description

Nicotinamide (or niacinamide) is a form of vitamin B3 that can be used in a variety of therapeutic applications. It is found in meat, fish, nuts, and mushrooms, as well as in some vegetables. It is an amide derivative of nicotinic acid and is preferred in the treatment of pellagra, acne and skin cancer.[1][2]
Nicotinamide-2,4,5,6-d₄ is a deuterated vitamin B3 wherein C-2, C-4, C-5, and C-6 pyridine protons are replaced by deuterium.

Application

Nicotinamide-2,4,5,6-d₄ can be used as a stable isotope internal standard for accurate data interpretation in samples by LC-MS.[3][4]

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Measurement of water-soluble B vitamins in infant formula by liquid chromatography/tandem mass spectrometry

Huang M, et al.

Journal of AOAC (Association of Official Analytical Chemists) International, 92(6), 1728-1738 (2009)

Contents of selected B vitamins in NIST SRM 3280 multivitamin/multielement tablets by liquid chromatography isotope dilution mass spectrometry

Chen P, et al.

Analytical and Bioanalytical Chemistry, 389(1), 343-347 (2007)

A review of nicotinamide: treatment of skin diseases and potential side effects

Rolfe HM

Journal of Cosmetic Dermatology, 13(4), 324-328 (2014)

Safety of high-dose nicotinamide: a review

Knip M, et al.

Diabetologia, 43(11), 1337-1345 (2000)

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Nicotinamide-2,4,5,6-d4