764760

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

PEG average M_n 2,000, PLGA average M_n 11,500

• Synonym(s): PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA
• Linear Formula: H[(C₃H₄O₂)_x(C₂H₂O₂)_y]_mO[C₂H₄O]_nCH₃
• UNSPSC Code: 12162002
• NACRES: NA.23

Properties

• form: pellets
• feed ratio: lactide:glycolide 50:50
• mol wt: PEG average M_n 2,000; PLGA average M_n 11,500; average M_n 13,500 (total)
• degradation timeframe: 1-4 weeks
• transition temp: T_m 298-303 °C; T_g 40 °C (PDLLA block); T_g 6 °C (PEG block)
• PDI: ≤2.0
• storage temp.: 2-8°C

Description

General description

Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part. [1]

Application

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.[2][3]

Features and Benefits

• Good biocompatibility, low immunogenicity and good degradability.
• Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.[1]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable