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764817

Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide)

average Mn (1100-1000-1100), lactide:glycolide 75:25

Synonym(s):

PLGA-PEG-PLGA

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About This Item

NACRES:
NA.23
UNSPSC Code:
12162002

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description

typical PEG PDI<1.1; overall PDI≤2.0 (THF, PS)

form

semisolid

feed ratio

lactide:glycolide 75:25

mol wt

PEG average Mn 1,000, PLGA average Mn 2,200, average Mn (1100-1000-1100)

degradation timeframe

2-3 weeks

transition temp

Tm 230-235 °C

PDI

<2.0

storage temp.

2-8°C

Quality Level

100

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This Item
908843909076765139
Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide) average Mn (1100-1000-1100), lactide:glycolide 75:25

Sigma-Aldrich

764817

Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide)

Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide) average Mn (1,600-1,500-1,600), lactide:glycolide 75:25

Sigma-Aldrich

908843

Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide)

Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide) average Mn (1,700-1,500-1,700), lactide:glycolide (95:5)

Sigma-Aldrich

909076

Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide)

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) PEG average Mn 5,000, PLGA Mn 7,000

Sigma-Aldrich

765139

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

form

semisolid

form

semisolid

form

semisolid

form

solid

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

description

typical PEG PDI<1.1; overall PDI≤2.0 (THF, PS)

description

-

description

-

description

-

feed ratio

lactide:glycolide 75:25

feed ratio

lactide:glycolide 75:25

feed ratio

lactide:glycolide (95:5)

feed ratio

lactide:glycolide 50:50

mol wt

PEG average Mn 1,000

mol wt

PEG average Mn 1,500 (by NMR), PLGA average Mn 3,200 (by NMR), average Mn (1,600-1,500-1,600)

mol wt

PEG average Mn 1,500 (by NMR), PLGA average Mn 3,400 (by NMR), average Mn (1,700-1,500-1,700)

mol wt

PEG average Mn 5,000, PLGA Mn 7,000, average Mn 12,000 (total)

degradation timeframe

2-3 weeks

degradation timeframe

-

degradation timeframe

-

degradation timeframe

1-4 weeks

General description

PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs.[1]

Application

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.[2][3]

Features and Benefits

Biocompatible, degradable, thermosensitive, high stability, small size (<200 nm) and properties can be easily modified.[1]

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCP0962
MKCP5201
MKCM8663
MKCM5667
MKCG3703

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Zhimei Song et al.
Journal of colloid and interface science, 354(1), 116-123 (2010-11-04)
The aim of this study was to assess the potential of new copolymeric micelles to modify the pharmacokenetics and tissue distribution of Curcumin (CUR), a hydrophobic drug. In the present study, a poly (d,l-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(d,l-lactide-co-glycolide) (PLGA-PEG-PLGA) copolymer was synthesized and
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., &amp; Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)

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