765449

Sigma-Aldrich

Gold nanoparticles

5 nm diameter, carboxylic acid functionalized, PEG 5000 coated, dispersion in H2O

Synonym(s):
Gold nanoparticles COOH functionalized, Gold Colloid, Au NP COOH
PubChem Substance ID:
NACRES:
NA.23
Pricing and availability is not currently available.

material

PEG 5000

form

dispersion in H2O
nanoparticles

packaging

glass bottle of 1 mL

OD

50

diameter

5 nm

pH

6.0-8.0 (25 °C)

solubility

water: miscible

density

1.00 g/cm3

λmax

515 nm

functional group

carboxyl

storage temp.

2-8°C

Application

Carboxylic acid functionalized, PEG 5000 coated and H2O dispersed gold nanoparticles (5 nm) can be potentially used in the development of biosensors, cancer-cell imaging, drug delivery, and photothermal therapy.
AuNPs may be used to prepare SARS-CoV-2 conjugate for COVID-19 detection using lateral flow immunoassay technique. It may also be used in immobilization of antibodies to improve the sensitivity of optical fiber sensors for the screening of COVID-19. It can also be deposited on the titanium electrode for the formation of a miniaturized device for the electrochemical detection of DNA hybridization.
Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

Packaging

1 mL in glass bottle

Features and Benefits

Decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. PEG increases the stability of the nanoparticles and prevents agglomeration.

Other Notes

  • form dispersion in H2O
  • OD 50
  • diameter 5 nm
  • storage temp. 2-8°C

RIDADR

NONH for all modes of transport

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Jennifer Mytych et al.
BioMed research international, 2015, 304575-304575 (2015-07-23)
Nanogold-based materials are promising candidate tools for nanobased medicine. Nevertheless, no conclusive information on their cytotoxicity is available. In the present study, we investigated the effects of gold nanoparticles (AuNPs) on human astrocytes in vitro. Nanogold treatment in a wide...
Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis
Li Z, et al.
Journal of Medical Virology, 6, 2071-2071 (2020)
Alexandre Albanese et al.
ACS nano, 5(7), 5478-5489 (2011-06-23)
Aggregation appears to be a ubiquitous phenomenon among all nanoparticles and its influence in mediating cellular uptake and interactions remain unclear. Here we developed a simple technique to produce transferrin-coated gold nanoparticle aggregates of different sizes and characterized their uptake...
Size-dependent in vivo toxicity of PEG-coated gold nanoparticles
Zhang X, et al.
International journal of nanomedicine, 6, 2071-2071 (2011)
Sarah D Brown et al.
Journal of the American Chemical Society, 132(13), 4678-4684 (2010-03-17)
The platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin are an important component of chemotherapy but are limited by severe dose-limiting side effects and the ability of tumors to develop resistance rapidly. These drugs can be improved through the use of...
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