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765554

Sigma-Aldrich

Gold nanoparticles

40 nm diameter, carboxylic acid functionalized, PEG 3000 coated, OD 50, dispersion in H2O

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Synonym(s):
Gold nanoparticles COOH functionalized, Au NP COOH, Gold Colloid
NACRES:
NA.23

material

PEG 3000

Quality Level

form

dispersion in H2O
nanoparticles

packaging

poly bottle of 1 mL

OD

50

diameter

40 nm

pH

6.0-8.0 (25 °C)

solubility

water: miscible

density

1.00 g/cm3

λmax

530 nm

functional group

carboxyl

storage temp.

2-8°C

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This Item
765511765473765538
Gold nanoparticles 40 nm diameter, carboxylic acid functionalized, PEG 3000 coated, OD 50, dispersion in H2O

Sigma-Aldrich

765554

Gold nanoparticles

Gold nanoparticles 20 nm diameter, carboxylic acid functionalized, PEG 5000 coated, OD 50, dispersion in H2O

Sigma-Aldrich

765511

Gold nanoparticles

Gold nanoparticles 15 nm diameter, carboxylic acid functionalized, PEG 3000 coated, OD 50, dispersion in H2O

Sigma-Aldrich

765473

Gold nanoparticles

Gold nanoparticles 30 nm diameter, carboxylic acid functionalized, PEG 3000 coated, OD 50, dispersion in H2O

Sigma-Aldrich

765538

Gold nanoparticles

functional group

carboxyl

functional group

carboxyl

functional group

carboxyl

functional group

carboxyl

material

PEG 3000

material

PEG 5000

material

PEG 3000

material

PEG 3000

packaging

poly bottle of 1 mL

packaging

poly bottle of 1 mL

packaging

glass bottle of 1 mL

packaging

poly bottle of 1 mL

OD

50

OD

50

OD

50

OD

50

diameter

40 nm

diameter

20 nm

diameter

15 nm

diameter

30 nm

General description

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. Carboxylic acid functionalized GNPs form conjugates with various protein molecules due to the electrostatic attraction between the negatively charged carboxylate groups and positively charged amino groups of protein. Since it adheres to cell membranes, it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.

Application

Several other specific applications have been listed below:
  • Since they adhere to cell membranes, AuNPs may find use in cellular and intracellular targeting in targeted drug delivery applications and may also be used in biodistribution studies.
  • AuNPs may also be used in photothermal therapy and radiotherapy.
  • AuNPs ranging from 10 to 250 nm, were studied to have been absorbed primarily by liver and spleen, when injected intravenously in rats.Whereas, 10 nm nanoparticles were distributed more broadly into various organs.
  • Carboxylic acid end-groups bind with various proteins and hence are used in targeted drug delivery and gene therapy.
Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

Features and Benefits

The PEG coating decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. PEG increases the stability of the nanoparticles and prevents agglomeration.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Nishima Wangoo et al.
Journal of colloid and interface science, 323(2), 247-254 (2008-05-20)
We report a novel strategy for the synthesis of aqueous stable, carboxylated gold nanoparticles (GNPs) by using glutamic acid as the reducing agent. The ratio of chloroaurate ions, AuCl(-)(4) to glutamic acid was optimized in the reaction medium to obtain
Xiao-Dong Zhang et al.
International journal of nanomedicine, 6, 2071-2081 (2011-10-07)
Gold nanoparticle toxicity research is currently leading towards the in vivo experiment. Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity. Here, we present the in vivo toxicity of
Timothy A Larson et al.
ACS nano, 6(10), 9182-9190 (2012-09-27)
Polyethylene glycol (PEG) surface coatings are widely used to render stealth properties to nanoparticles in biological applications. There is abundant literature on the benefits of PEG coatings and their ability to reduce protein adsorption, to diminish nonspecific interactions with cells
Functionalized gold nanoparticles and their biomedical applications
Tiwari, P. M., Vig, K., Dennis, V. A., & Singh, S. R.
Nanomaterials, 1(1), 31-63 (2011)

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