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765589

Sigma-Aldrich

Gold nanoparticles

50 nm diameter, carboxylic acid functionalized, PEG 5000 coated, dispersion in H2O

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Synonym(s):
Gold nanoparticles COOH functionalized, Au NP COOH, Gold Colloid
NACRES:
NA.23

material

PEG 5000

form

dispersion in H2O
nanoparticles

packaging

poly bottle of 1 mL

OD

50

diameter

50 nm

pH

6.0-8.0 (25 °C)

solubility

water: miscible

density

1.00 g/cm3

λmax

535 nm

functional group

carboxyl

storage temp.

2-8°C

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1 of 4

This Item
765538765511765457
vibrant-m

765589

Gold nanoparticles

vibrant-m

765538

Gold nanoparticles

vibrant-m

765511

Gold nanoparticles

vibrant-m

765457

Gold nanoparticles

functional group

carboxyl

functional group

carboxyl

functional group

carboxyl

functional group

carboxyl

material

PEG 5000

material

PEG 3000

material

PEG 5000

material

PEG 3000

packaging

poly bottle of 1 mL

packaging

poly bottle of 1 mL

packaging

poly bottle of 1 mL

packaging

glass bottle of 1 mL

OD

50

OD

50

OD

50

OD

50

diameter

50 nm

diameter

30 nm

diameter

20 nm

diameter

10 nm

General description

Carboxylic acid functionalized GNPs forms conjugates with various protein molecules due to the electrostatic attraction between negatively charged carboxylate groups and positively charged amino groups of protein.

Application

Gold nanoparticles 50 nm diameter, carboxylic acid functionalized, PEG 5000 coated, dispersion in H2O can be potentially used in the development of biosensors, cancer-cell imaging, drug delivery, and photothermal therapy.
AuNPs may also be used in the immobilization of antibodies to improve the sensitivity of optical fiber sensors for the screening of COVID-19. It can also be deposited on the titanium electrode for the formation of a miniaturized device for the electrochemical detection of DNA hybridization.
The carboxylic acid group binds with proteins and is used in targeted drug delivery and gene therapy.
Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Functionalized gold nanoparticles and their biomedical applications
Nanomaterials, 1(1), 31-63 (2011)
Optical Fiber Sensors for Rapid Screening of COVID-19
Nag P, et al.
Transactions of the Indian National Academy of Engineering, 6, 1-4 (2020)
Size-dependent in vivo toxicity of PEG-coated gold nanoparticles
Zhang X, et al.
International journal of nanomedicine, 6, 2071-2071 (2011)
Nishima Wangoo et al.
Journal of colloid and interface science, 323(2), 247-254 (2008-05-20)
We report a novel strategy for the synthesis of aqueous stable, carboxylated gold nanoparticles (GNPs) by using glutamic acid as the reducing agent. The ratio of chloroaurate ions, AuCl(-)(4) to glutamic acid was optimized in the reaction medium to obtain

Articles

The recent emergence of a number of highly functional nanomaterials has enabled new approaches to the understanding, diagnosis, and treatment of cancer.

Biomaterials science involves the design and fabrication of smart materials for studying, directing, or mimicking biology. For successful integration of biomaterials in biological research, a meaningful understanding of biological systems is required.

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