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2,2-Bis(aminoethoxy)propane

≥98%

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Synonym(s):
2,2′-[(1-Methylethylidene)bis(oxy)]bis(ethanamine), 2,2-Di(2-aminoethoxy)propane, Diamino ketal
Empirical Formula (Hill Notation):
C7H18N2O2
CAS Number:
Molecular Weight:
162.23
MDL number:
PubChem Substance ID:
NACRES:
NA.23

Assay

≥98%

form

liquid

refractive index

n20/D 1.458

bp

202-214/760 mmHg

density

1.018 g/mL at 25 °C

SMILES string

CC(C)(OCCN)OCCN

InChI

1S/C7H18N2O2/c1-7(2,10-5-3-8)11-6-4-9/h3-6,8-9H2,1-2H3

InChI key

YDMYVTCIPQGGPB-UHFFFAOYSA-N

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This Item
385506394111157716
BIS-TRIS propane ULTROL® Grade, >98% (titration), non-zwitterionic buffer useful in pH range 6.3-9.5

Millipore

394111

BIS-TRIS propane

form

liquid

form

liquid

form

solid

form

liquid

refractive index

n20/D 1.458

refractive index

n20/D 1.461 (lit.)

refractive index

-

refractive index

n20/D 1.532 (lit.)

bp

202-214/760 mmHg

bp

105-109 °C/6 mmHg (lit.)

bp

-

bp

257 °C (lit.)

density

1.018 g/mL at 25 °C

density

1.015 g/mL at 25 °C (lit.)

density

-

density

0.94 g/mL at 25 °C (lit.)

General description

2,2-Bis(aminoethoxy)propane is an acid degradable amine monomer that can be used as a ketal containing cross-linker. It is a pH sensitive molecule that is used in the synthesis of polyurea and polyurethane.

Application

2,2-Bis(aminoethoxy)propane can be used in the preparation of biocompatible polymeric materials for the development of controlled drug delivery systems.
This homobifunctionalized amino ketal is primarily used in crosslinking cell lysate (linking polypeptides whose lysine side chains are nearest to each other). Primary amines commonly conjugate through acylation or alkylation of isothiocyanates; isocyanates; acyl azides; NHS esters; sulfonyl chlorides; aldehydes; carbonates; aryl halides; imidoesters; carbodiimides; anhydrides; and fluorophenyl esters. This diamine can also crosslink epoxies.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

224.0 °F

Flash Point(C)

106.67 °C


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Ketal cross-linked poly (ethylene glycol)-poly (amino acid) s copolymer micelles for efficient intracellular delivery of doxorubicin
Lee SJ, et al.
Biomacromolecules, 12(4), 1224-1233 (2011)
Acid degradable cross-linked micelles for the delivery of cisplatin: a comparison with nondegradable cross-linker
Huynh VT, et al.
Chemistry of Materials, 24(16), 3197-3211 (2012)
Fully acid-degradable biocompatible polyacetal microparticles for drug delivery
Paramonov SE, et al.
Bioconjugate Chemistry, 19(4), 911-919 (2008)
Maria C Arno et al.
Biomaterials, 180, 184-192 (2018-07-27)
The physical properties of cyclic and linear polymers are markedly different; however, there are few examples which exploit these differences in clinical applications. In this study, we demonstrate that self-assemblies comprised of cyclic-linear graft copolymers are significantly more stable than
Controlled delivery of plasmid DNA and siRNA to intracellular targets using ketalized polyethylenimine
Shim MS and Kwon YJ
Biomacromolecules, 9(2), 444-455 (2008)

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