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774405

Sigma-Aldrich

(S)-2-Aminobutane-1,4-dithiol hydrochloride

99% (titration)

All Photos(1)
Synonym(s):
(S)-2-Aminobutane-1,4-dithiol hydrochloride, (2S)-2-Amino-1,4-dimercaptobutane hydrochloride, DTBA, Dithiobutylamine
Empirical Formula (Hill Notation):
C4H11NS2 · HCl
CAS Number:
1363376-98-0
Molecular Weight:
173.73
MDL number:
MFCD23704430
PubChem Substance ID:
329767683
NACRES:
NA.22

Quality Level

100

Assay

99% (titration)

form

solid

reaction suitability

reagent type: reductant

mp

210-225 °C

storage temp.

2-8°C

SMILES string

Cl.N[C@H](CS)CCS

InChI

1S/C4H11NS2.ClH/c5-4(3-7)1-2-6;/h4,6-7H,1-3,5H2;1H/t4-;/m0./s1

InChI key

HWWPXJZINVJNBM-WCCKRBBISA-N

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(S)-2-Aminobutane-1,4-dithiol hydrochloride 99% (titration)

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assay

99% (titration)

assay

97%

assay

≥99% (titration)

assay

98%

form

solid

form

solid

form

powder

form

-

reaction suitability

reagent type: reductant

reaction suitability

reagent type: cross-linking reagent

reaction suitability

-

reaction suitability

-

mp

210-225 °C

mp

162-164 °C (lit.)

mp

-

mp

73-76 °C (lit.)

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

-

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

Application

(S)-2-Aminobutane-1,4-dithiol hydrochloride (DTBA), also known as dithiobutylamine, is a biological reducing reagent with enhanced properties over other commonly used reagents. DTBA was shown to reduce small molecule disulfides 3-5x faster than DTT and was able to reduce (activate) the cysteine dependent protease papain 14x faster than DTT. In addition, due to the presence of the primary amine group, removal of DTBA from mixtures after use is simplified and can be achieved using cation exchange resin.
Dithiobutylamine or DTBA is a new biological reducing reagent with enhanced properties over other commonly used reagents. DTBA was shown to reduce small molecule disulfides 3-5x faster than DTT and was able to reduce (activate) the cysteine dependent protease papain 14x faster than DTT. In addition, due to the presence of the primary amine group, removal of DTBA from mixtures after use is simplified and can be achieved using cation exchange resin.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302 - H315 - H319 - H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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