774766

Lithium diisopropylamide solution

1.0 M in THF/hexanes

• Synonym(s): LDA
• Linear Formula: [(CH₃)₂CH]₂NLi
• CAS Number: 4111-54-0
• Molecular Weight: 107.12
• Beilstein: 3655042
• MDL number: MFCD00064449
• PubChem Substance ID: 329767712
• NACRES: NA.22

Properties

• Quality Level: 100
• concentration: 1.0 M in THF/hexanes
• density: 0.719 g/mL at 25 °C
• storage temp.: 2-8°C
• SMILES string: [Li]N(C(C)C)C(C)C
• InChI: 1S/C6H14N.Li/c1-5(2)7-6(3)4;/h5-6H,1-4H3;/q-1;+1
• InChI key: ZCSHNCUQKCANBX-UHFFFAOYSA-N

Description

General description

This material is in a solution of THF/Hexanes (ca. 1:7 ratio, respectively)

Application

Titanium-ate enolates prepared from ketones by Ti(OiPr)4 and LDA underwent efficient radical trifluoromethylation providing trifluoromethyl ketones in good yield. Used in directed ortho-lithiation of arylsulfonyloxazolidinones to prepare N-substituted saccharin analogs.

Packaging

4×25, 100, 500 mL in Sure/Seal™

The 25 mL Sure/Seal^™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

Legal Information

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Safety Information

• Pictograms: GHS02,GHS05,GHS07,GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H225 - H302 - H304 - H314 - H335 - H336 - H351 - H361f - H373 - H411
• Precautionary Statements: P210 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 2 - Asp. Tox. 1 - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Corr. 1B - STOT RE 2 Inhalation
• Supplementary Hazards: EUH018 - EUH019
• Storage Class Code: 4.3 - Hazardous materials, which set free flammable gases upon contact with water
• WGK Germany: WGK 3
• Flash Point(F): -22.0 °F
• Flash Point(C): -30 °C